Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Atrial fibrillation (AF) is the most frequent arrhythmia managed in clinical practice, and it is
linked to an increased risk of death, stroke, and peripheral embolism. The Global Burden of …

Importance Ablation of persistent atrial fibrillation (AF) remains a challenge. Left atrial
fibrosis plays an important role in the pathophysiology of AF and has been associated with …

Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …

Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Heart failure (HF) is considered as a severe health problem worldwide, while cardiac fibrosis
is one of the main driving factors for the progress of HF. Cardiac fibrosis was characterized …

Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …

Background: The role of epicardial fat (eFat)-derived extracellular vesicles (EVs) in the
pathogenesis of atrial fibrillation (AF) has never been studied. We tested the hypothesis that …

In addition to their use in relieving the symptoms of various diseases, ketogenic diets (KDs)
have also been adopted by healthy individuals to prevent being overweight. Herein, we …