Red Light‐Triggered Anti‐Angiogenic and Photodynamic Combination Therapy of Age‐Related Macular Degeneration

S Xu, K Cui, K Long, J Li, N Fan, WC Lam… - Advanced …, 2023 - Wiley Online Library
Choroidal neovascularization (CNV) is the key pathological event of wet age‐related
macular degeneration (wAMD) leading to irreversible vision loss. Currently, anti‐angiogenic …

[HTML][HTML] Ultrasound-induced drug release from stimuli-responsive hydrogels

TJ Yeingst, JH Arrizabalaga, DJ Hayes - Gels, 2022 - mdpi.com
Stimuli-responsive hydrogel drug delivery systems are designed to release a payload when
prompted by an external stimulus. These platforms have become prominent in the field of …

Calcium peroxide nanoparticles induce endoplasmic reticulum stress for enhanced radiation therapy of osteosarcoma

Z Liu, Z Fu, M Zhao, H Wang, X Ji, J Zhou, W Gu, Y Gu… - Nano Today, 2024 - Elsevier
Radiation therapy (RT) has been widely used in clinics. The expression of various radiation-
resistant proteins limits the curative effect of RT. Endoplasmic reticulum (ER) plays a critical …

Amino Acid‐Starved Cancer Cells Utilize Macropinocytosis and Ubiquitin‐Proteasome System for Nutrient Acquisition

T Wang, Y Zhang, Y Liu, Y Huang… - Advanced Science, 2024 - Wiley Online Library
To grow in nutrient‐deprived tumor microenvironment, cancer cells often internalize and
degrade extracellular proteins to refuel intracellular amino acids. However, the nutrient …

Tailoring drug delivery systems by microfluidics for tumor therapy

Q Zhang, G Kuang, L Wang, L Fan, Y Zhao - Materials Today, 2024 - Elsevier
Drug delivery systems (DDSs) for tumor treatment is a specialized method aimed at
transporting therapeutic substances, especially anticancer drugs, to specific target areas in …

Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole–Electron Analysis

H He, Z Wang, X Peng, L Qing, Y Zhang… - Journal of Medicinal …, 2024 - ACS Publications
Small molecules capable of modulating methionine adenosyltransferase 2A (MAT2A) are of
significant interest in precise cancer therapeutics. Herein, we raised the hole–electron …

[HTML][HTML] Cerium oxide-based nanozyme suppresses kidney calcium oxalate crystal depositions via reversing hyperoxaluria-induced oxidative stress damage

J Deng, B Yu, Z Chang, S Wu, G Li, W Chen… - Journal of …, 2022 - Springer
Oxidative stress damage to renal epithelial cells is the main pathological factor of calcium
oxalate calculi formation. The development of medicine that could alleviate oxidative …

Nanoplatform‐based in vivo gene delivery systems for cancer therapy

R Luo, H Le, Q Wu, C Gong - Small, 2024 - Wiley Online Library
Gene therapy uses modern molecular biology methods to repair disease‐causing genes. As
a burgeoning therapeutic, it has been widely applied for cancer therapy. Since 1989, there …

Boosting the immunoactivity of T cells by resonant thermal radiation from electric graphene films for improved cancer immunotherapy

C Shi, W Fu, X Zhang, Q Zhang, F Zeng… - Advanced …, 2023 - Wiley Online Library
To investigate the effect of resonant thermal radiation from electric graphene films (GFs) to
the immunoactivity of T cells in situ and the benefits to cancer immunotherapy. This work …

Ultrasound nanomedicine and materdicine

Z Wang, X Wang, M Chang, J Guo… - Journal of Materials …, 2023 - pubs.rsc.org
The conventional microbubble-based ultrasound biomedicine clinically plays a vital role in
providing the dynamic detection of macro and microvasculature and disease theranostics …