[PDF][PDF] GDF15: a hormone conveying somatic distress to the brain
GDF15 has recently gained scientific and translational prominence with the discovery that its
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …
Coping with stress: the mitokine GDF-15 as a biomarker of COVID-19 severity
Growth differentiation factor 15 (GDF-15) is a transforming growth factor (TGF)-β superfamily
cytokine that plays a central role in metabolism regulation. Produced in response to …
cytokine that plays a central role in metabolism regulation. Produced in response to …
GDF15 is an inflammation-induced central mediator of tissue tolerance
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with
poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral …
poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral …
Reference ranges for GDF-15, and risk factors associated with GDF-15, in a large general population cohort
Objectives Growth differentiation factor (GDF)-15 is attracting interest as a biomarker in
several areas of medicine. We aimed to evaluate the reference range for GDF-15 in a …
several areas of medicine. We aimed to evaluate the reference range for GDF-15 in a …
GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is the most common and devastating of the interstitial
lung diseases. Epithelial dysfunction is thought to play a prominent role in disease …
lung diseases. Epithelial dysfunction is thought to play a prominent role in disease …
GDF15 as a key disease target and biomarker: Linking chronic lung diseases and ageing
Y Wan, J Fu - Molecular and cellular biochemistry, 2024 - Springer
Abstract Growth differentiation factor 15 (GDF15), a member of the transforming growth
factor-beta superfamily, is expressed in several human organs. In particular, it is highly …
factor-beta superfamily, is expressed in several human organs. In particular, it is highly …
Gastrointestinal inflammation plays a critical role in chemotherapy-induced nausea and vomiting
W Chen, Y Zhao, Y Dai, K Nie - European Journal of Pharmacology, 2022 - Elsevier
Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of patients with
cancer receiving chemotherapeutic drugs. However, the pathological mechanism of CINV is …
cancer receiving chemotherapeutic drugs. However, the pathological mechanism of CINV is …
Role of growth differentiation factor 15 in lung disease and senescence: potential role across the lifespan
F Al-Mudares, S Reddick, J Ren, A Venkatesh… - Frontiers in …, 2020 - frontiersin.org
Growth Differentiation Factor 15 (GDF15) is a divergent member of transforming growth
factor-beta (TGF-β) superfamily and is ubiquitously expressed, under normal physiological …
factor-beta (TGF-β) superfamily and is ubiquitously expressed, under normal physiological …
Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease
M Li, L Duan, YL Cai, HY Li, BC Hao, JQ Chen… - Cardiovascular …, 2020 - Springer
Background Growth differentiation factor-15 (GDF-15) is a marker of inflammation, oxidative
stress and it is associated with adverse prognosis in cardiovascular disease. The aim of the …
stress and it is associated with adverse prognosis in cardiovascular disease. The aim of the …
Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice
F Al-Mudares, M Cantu Gutierrez… - … of Physiology-Lung …, 2023 - journals.physiology.org
Growth differentiation factor 15 (GDF15) is a divergent member of the transforming growth
factor-β (TGF-β) superfamily, and its expression increases under various stress conditions …
factor-β (TGF-β) superfamily, and its expression increases under various stress conditions …