Acute lung injury (ALI) is a complex disease with numerous causes. This review begins with
a discussion of disease development from direct or indirect pulmonary insults, as well as …

Background International guidelines suggest using a higher (> 10 cm H 2 O) positive end-
expiratory pressure (PEEP) in patients with moderate-to-severe ARDS due to COVID-19 …

Since its very first description, understanding the acute respiratory distress syndrome
(ARDS) has been a major research and clinical challenge due to heterogeneity in causes …

Background Acute respiratory distress syndrome remains a heterogeneous syndrome for
clinicians and researchers difficulting successful tailoring of interventions and trials. To this …

Purpose To describe the clinical course of ARDS during the first three days of mechanical
ventilation, to compare ventilatory setting, respiratory mechanics and gas exchange …

Background To develop and validate classifier models that could be used to identify patients
with a high percentage of potentially recruitable lung from readily available clinical data and …

Objectives: Different techniques exist to select personalized positive end-expiratory pressure
in patients affected by the acute respiratory distress syndrome. The positive end-expiratory …

Background The ARDS is characterized by different degrees of impairment in oxygenation
and distribution of the lung disease. Two radiological patterns have been described: a focal …

Background: Lung-protective ventilation (LPV) strategies have been beneficial in patients
with acute respiratory distress syndrome (ARDS). As a vital part of LPV, positive end …

Dead space represents the volume of ventilated air that does not participate in gas
exchange. The two types of dead space are anatomical dead space and physiologic dead …