The cardinal motor symptoms of Parkinson's disease (PD) are caused by the death of
dopaminergic neurons in the substantia nigra pars compacta (SN c). Alpha‐synuclein …

Clinical–pathological studies remain the gold‐standard for the diagnosis of Parkinson's
disease (PD). However, mounting data from genetic PD autopsies challenge the diagnosis …

The cause of Parkinson's disease (PD) remains unknown in most patients. Since 1997, with
the first genetic mutation known to cause PD described in SNCA gene, many other genes …

Summary Synaptojanin 1 (SJ1) is a major presynaptic phosphatase that couples synaptic
vesicle endocytosis to the dephosphorylation of PI (4, 5) P 2, a reaction needed for the …

Lipid interaction with α-synuclein (αSyn) has been long implicated in the pathogenesis of
Parkinson's disease (PD). However, it has not been fully determined which lipids are …

Parkinson's disease (PD) is a leading cause of neurodegeneration that is defined by the
selective loss of dopaminergic neurons and the accumulation of protein aggregates called …

Abstract Trisomy 21 (T21) causes Down syndrome and an early-onset form of Alzheimer's
disease (AD). Here, we used human induced pluripotent stem cells (hiPSCs) along with …

This mini-review aims to summarize a growing body of literature on synaptojanin 1 (Synj1), a
phosphoinositide phosphatase that was initially known to have a prominent role in synaptic …

The complex morphology of neurons, the specific requirements of synaptic
neurotransmission and the accompanying metabolic demands create a unique challenge for …

Complex genetic predispositions accelerate the chronic degeneration of midbrain substantia
nigra neurons in Parkinson's disease (PD). Deciphering the human molecular makeup of PD …