Humoral Innate Immunity and Acute-Phase Proteins | NEJM Skip to main content NEJM Group
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Genetic, environmental, and aging-related insults can promote the misfolding and
subsequent aggregation of secreted proteins implicated in the pathogenesis of numerous …

The WHO reports heart diseases, especially MI, are the leading cause of death. During a
heart attack and damage to myocardial cells, cardiac biomarkers are released into the …

Serum amyloid A (SAA) subtypes 1-3 are well-described acute phase reactants that are
elevated in acute inflammatory conditions such as infection, tissue injury, and trauma, while …

Hepatic innate immune function plays an important role in the pathogenesis of many
diseases. Importantly, a growing body of literature has firmly established the spatial …

The therapeutic administration of recombinant proteins is utilized in a multitude of research
studies for treating various diseases. In this study, we investigate the therapeutic potential of …

Diabetes is a highly common metabolic disorder in advanced societies. One of the causes of
diabetes is insulin resistance, which is associated with a loss of sensitivity to insulin …

Background & Aims Liver fibrosis represents a hallmark of most chronic liver diseases (CLD)
triggered by recurrent liver injury and subsequent myofibroblast transdifferentiations of …

Disruption of circadian rhythms occurs in rotating shift-work, jetlag, and in individuals with
irregular sleep schedules. Circadian disruption is known to alter inflammatory responses …

From the discovery of pleurocidin in skin mucus of winter flounder, many new related
sequences have been found, forming a fish-exclusive family of antimicrobial peptides (AMP) …