Iron (II) species can participate in the Fenton and Fenton‐like reactions to generate the
hydroxyl radical that can oxidatively damage biomolecules and induce oxidative stress in …

Several measures are in place to combat the worldwide spread of malaria, especially in
regions of high endemicity. In part, most common antimalarials, such as quinolines and …

Malaria remains a major public health disease due to its high yearly mortality and morbidity.
Resistance to the gold standard drug, artemisinin, is worrisome and needs better …

Understanding the mode of action of antimalarials is central to optimizing their use and the
discovery of new therapeutics. Currently used antimalarials belong to a limited series of …

Mesenchymal stem cells are undifferentiated cells able to acquire different phenotypes
under specific stimuli. Wharton's jelly is a tissue in the umbilical cord that contains …

Reactive oxygen species (ROS) are critical for many cellular functions, and dysregulation of
ROS involves the development of multiple types of tumors, including pancreatic cancer …

Extracellular vesicles (EVs) are found in all biological fluids, providing potential for the
identification of disease biomarkers such as colorectal cancer (CRC). EVs are heavily …

In red blood cells, hemoglobin iron represents the most plausible candidate to catalyze
artemisinin activation but the limited reactivity of iron bound to hemoglobin does not play in …

The proteomic profiling of serum samples supposes a challenge due to the large abundance
of a few blood proteins in comparison with other circulating proteins coming from different …

Erythrocytes are highly specialized cells in human body, and their main function is to ensure
the gas exchanges, O2 and CO2, within the body. The exposure to microgravity environment …