Ribosome biogenesis: a central player in cancer metastasis and therapeutic resistance

AR Elhamamsy, BJ Metge, HA Alsheikh, LA Shevde… - Cancer research, 2022 - AACR
Ribosomes are a complex ensemble of rRNA and ribosomal proteins that function as mRNA
translation machines. Ribosome biogenesis is a multistep process that begins in the …

Ribosome biogenesis in disease: new players and therapeutic targets

L Jiao, Y Liu, XY Yu, X Pan, Y Zhang, J Tu… - … and Targeted Therapy, 2023 - nature.com
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

Microfluidics-free single-cell genomics with templated emulsification

IC Clark, KM Fontanez, RH Meltzer, Y Xue… - Nature …, 2023 - nature.com
Current single-cell RNA-sequencing approaches have limitations that stem from the
microfluidic devices or fluid handling steps required for sample processing. We develop a …

Improving mesophilic anaerobic digestion of food waste by side-stream thermophilic reactor: Activation of methanogenic, key enzymes and metabolism

W Li, L Zhu, B Wu, Y Liu, J Li, L Xu, X Huangfu, D Shi… - Water Research, 2023 - Elsevier
Anaerobic digestion (AD) is a favorable way to convert organic pollutants, such as food
waste (FW), into clean energy through microbial action. This work adopted a side-stream …

Deregulation of ribosomal proteins in human cancers

W El Khoury, Z Nasr - Bioscience Reports, 2021 - portlandpress.com
The ribosome, the site for protein synthesis, is composed of ribosomal RNAs (rRNAs) and
ribosomal proteins (RPs). The latter have been shown to have many ribosomal and …

[HTML][HTML] Targeting the nucleolus as a therapeutic strategy in human disease

A Corman, O Sirozh, V Lafarga… - Trends in Biochemical …, 2023 - cell.com
The nucleolus is the site of ribosome biogenesis, one of the most resource-intensive
processes in eukaryotic cells. Accordingly, nucleolar morphology and activity are highly …

A new frontier in Fanconi anemia: From DNA repair to ribosome biogenesis

A Gueiderikh, F Maczkowiak-Chartois, F Rosselli - Blood reviews, 2022 - Elsevier
Abstract Described by Guido Fanconi almost 100 years ago, Fanconi anemia (FA) is a rare
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …

The dsRNA delivery, targeting and application in pest control

Y Lu, X Deng, Q Zhu, D Wu, J Zhong, L Wen, X Yu - Agronomy, 2023 - mdpi.com
RNA interference (RNAi) is a simple and rapid method for silencing genes in various
organisms, and it is widely used in gene function and genetics research. RNAi has been …

Amelioration of gamma irradiation‐induced salivary gland damage in mice using melatonin

J Ren, T Zhu, Z Wang, L Lu… - Journal of Pineal Research, 2023 - Wiley Online Library
Salivary gland damage caused by ionizing radiation (IR) severely affects the patient quality
of life and influences the efficacy of radiotherapy. Most current treatment modalities are …

Novel 2-(5-Aryl-4, 5-dihydropyrazol-1-yl) thiazol-4-one as EGFR inhibitors: synthesis, biological assessment and molecular docking insights

T Al-Warhi, AM El Kerdawy, MA Said… - Drug Design …, 2023 - Taylor & Francis
Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …