P53: A key player in diverse cellular processes including nuclear stress and ribosome biogenesis, highlighting potential therapeutic compounds

G Temaj, S Chichiarelli, P Telkoparan-Akillilar… - Biochemical …, 2024 - Elsevier
The tumor suppressor proteins are key transcription factors involved in the regulation of
various cellular processes, such as apoptosis, DNA repair, cell cycle, senescence, and …

Transcriptome Profiling Revealed Basis for Growth Heterosis in Hybrid Tilapia (Oreochromis niloticus ♀ × O. aureus ♂)

J Zhu, Z Zou, D Li, W Xiao, J Yu, B Chen, L Xue… - Fishes, 2022 - mdpi.com
Hybrid tilapia were produced from hybridization of Nile tilapia (Oreochromis niloticus) and
blue tilapia (O. aureus). Comparative transcriptome analysis was carried out on the liver of …

[HTML][HTML] Inhibition of TAF1B impairs ribosome biosynthesis and suppresses cell proliferation in stomach adenocarcinoma through promoting c-MYC mRNA …

H Chen, Z Li, Q Wu, C Yu, JY Yan, Y Bai, S Zhu, M Qian… - Heliyon, 2024 - cell.com
Hyperactivation of ribosome biosynthesis (RiBi) is a hallmark of cancer, and targeting
ribosome biogenesis has emerged as a potential therapeutic strategy. The depletion of …

Human oral mucosa and oral microbiome interactions following supragingival plaque reconstitution in healthy volunteers: a diet-controlled balanced design proof-of …

JLC Mougeot, MF Beckman, DS Morton… - Journal of Oral …, 2023 - Taylor & Francis
Changes in the oral microbiome may contribute to oral pathologies, especially in patients
undergoing cancer therapy. Interactions between oral microbiome and oral mucosa may …

Domain definition and preliminary functional exploration of the endonuclease NOBP-1 in Strongyloides stercoralis

H Zhou, W Yuan, W Lei, T Zhou, P Qin, B Zhang… - Parasites & …, 2023 - Springer
Background Ribosome biogenesis is the process of assembling ribosome complexes that
regulate cell proliferation and differentiation with potential regulatory effects on …

[HTML][HTML] Identification of Key Genes and Pathways in Duck Fatty Liver Syndrome using Gene Set Enrichment Analysis

X Yang, H Lin, M Wang, X Huang, K Li, W Xia, Y Zhang… - Poultry Science, 2024 - Elsevier
High-laying ducks are often fed high-energy, nutritious feeds to maintain high productivity,
which predisposes them to lipid metabolism disorders and the development of fatty liver …

Mutations of ribosomal protein genes induce overexpression of catalase in Saccharomyces cerevisiae

CH Hsu, CY Liu, KY Lo - FEMS Yeast Research, 2024 - academic.oup.com
Ribosome assembly defects result in ribosomopathies, primarily caused by inadequate
protein synthesis and induced oxidative stress. This study aimed to investigate the link …

Peripheral Blood Gene Expression Profiling Reveals Molecular Pathways Associated with Cervical Artery Dissection

PS Shlapakova, LA Dobrynina… - International Journal of …, 2024 - mdpi.com
Cervical artery dissection (CeAD) is the primary cause of ischemic stroke in young adults.
Monogenic heritable connective tissue diseases account for fewer than 5% of cases of …

[HTML][HTML] Integrated top-down and bottom-up proteomics mass spectrometry for the characterization of endogenous ribosomal protein heterogeneity

Y Zhang, Q Cai, Y Luo, Y Zhang, H Li - Journal of Pharmaceutical Analysis, 2023 - Elsevier
Ribosomes are abundant, large RNA-protein complexes that are the sites of all protein
synthesis in cells. Defects in ribosomal proteins (RPs), including proteoforms arising from …

[HTML][HTML] Identification of new aptamer BC-3 targeting RPS7 from rapid screening for bladder carcinoma

Y Liu, J Li, H Ou, D Qi, B Hu, Y Xu, J Hu, Y Xiong, L Xia… - Genes & …, 2023 - Elsevier
Aptamers, short single DNA or RNA oligonucleotides, have shown immense application
potential as molecular probes for the early diagnosis and therapy of cancer. However …