The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide
consideration because of their immense potential for immunomodulation and their …

Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

Left ventricular hypertrophy is a leading risk factor for cardiovascular morbidity and mortality.
Although reverse ventricular remodelling was long thought to be irreversible, evidence from …

Background: Right ventricular (RV) function is the major determinant for both functional
capacity and survival in patients with pulmonary arterial hypertension (PAH). Despite the …

The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …

Background/Aims. Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs
that regulate gene expression in eukaryotes. Recently, exosomes from cardiomyocytes …

Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-
CMs) is essential for their effective application in models of cardiac toxicity and disease …

Aims Cell therapy trials using cardiac-resident progenitor cells (CPCs) and bone marrow-
derived mesenchymal stem/progenitor cells (BMCs) in patients after myocardial infarction …

Alternative splicing (AS) of protein-coding messenger RNAs is an essential regulatory
mechanism in eukaryotic gene expression that controls the proper function of proteins. It is …