Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

The respiratory epithelium is the major interface between the environment and the host.
Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have …

Molecular mechanisms of surfactant delivery to the air/liquid interface in the lung, which is
crucial to lower the surface tension, have been studied for more than two decades. Lung …

Glycans are carbohydrate modifications typically found on proteins or lipids, and can act as
ligands for glycan-binding proteins called lectins. Glycans and lectins play crucial roles in …

Surfactant proteins A (SP-A) and D (SP-D) have been implicated in pulmonary innate
immunity. The proteins are host defense lectins, belonging to the collectin family which also …

Influenza viruses cause seasonal epidemics and sporadic pandemics in humans. The
virus's ability to change its antigenic nature through mutation and recombination, and the …

This review is focused on the evolution and function of alveolar proteins. The lung faces
physical and environmental challenges, due to changing pressures/volumes and foreign …

Influenza A viruses (IAVs) remain a major health threat and a prime example of the
significance of innate immunity. Our understanding of innate immunity to IAV has grown …

Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of
animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular …

Abstract Surfactant protein D (SP-D) is a collectin protein synthesized by alveolar type II cells
in the lungs. SP-D participates in the innate immune defense of the lungs by helping to clear …