Chronic pain and pruritus are highly disabling pathologies that still lack appropriate
therapeutic intervention. At cellular level the transduction and transmission of pain and …

Neuropathic Pain (NPP) is caused by direct or indirect damage to the nervous system and is
a common symptom of many diseases. Clinically, drugs are usually used to suppress pain …

Extracellular nucleosides and nucleotides have widespread functions in responding to
physiological stress. The “purinome” encompasses 4 G-protein-coupled receptors (GPCRs) …

Chromaffin cells (CCs) of the adrenal gland and the sympathetic nervous system produce
the catecholamines (epinephrine and norepinephrine; EPI and NE) needed to coordinate …

Aging is a risk factor for the development of osteoarthritis (OA), a progressive joint disease
leading to cartilage damage, pain, and loss of function. In a mouse model of OA, senolytic …

Abstract The P2X7 receptor (P2X7R) is a ligand-gated receptor belonging to the P2 receptor
family. It is distributed in various tissues of the human body and is involved in regulating the …

Neuropathic pain is a common clinical symptom of various diseases, and it seriously affects
the physical and mental health of patients. Owing to the complex pathological mechanism of …

The transient receptor potential vanilloid 1 (TRPV1), a ligand-gated nonselective cation
channel, is well known for mediating heat and pain sensation in the periphery. Increasing …

Aims This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and
TRPM8 channels in human systems at the transcriptional level. Main methods Using the …

Background and Purpose P2Y12 receptors regulate different forms of pain and
inflammation. In this study, we investigated the participation of P2Y12 receptors in an animal …