[HTML][HTML] Kirenol: a potential natural lead molecule for a new drug design, development, and therapy for inflammation

NN Nasir, M Sekar, S Fuloria, SH Gan, NNIM Rani… - Molecules, 2022 - mdpi.com
Kirenol, a potential natural diterpenoid molecule, is mainly found in Sigesbeckia species.
Kirenol has received a lot of interest in recent years due to its wide range of pharmacological …

The isolation of water-soluble natural products–challenges, strategies and perspectives

RGS Berlinck, CM Crnkovic, JR Gubiani… - Natural Product …, 2022 - pubs.rsc.org
Covering period: up to 2019 Water-soluble natural products constitute a relevant group of
secondary metabolites notably known for presenting potent biological activities. Examples …

Enantioselective Total Synthesis of (+)-KB343

C Bi, Y Wang, C He, PS Baran - Journal of the American Chemical …, 2023 - ACS Publications
A concise total synthesis of the complex guanidinium toxin KB343 is reported traversing
through an unusual sequence of chemoselective transformations and strategic skeletal …

Stable Isotope-Guided Metabolomics Reveals Polar-Functionalized Fatty-Acylated RiPPs from Streptomyces

S Asamizu, S Ijichi, S Hoshino, H Jo… - ACS Chemical …, 2022 - ACS Publications
Ribosomally synthesized and posttranslationally modified peptides (RiPPs) with polar-
functionalized fatty acyl groups are a rarely found untapped class of natural products …

Sponges present a core prokaryotic community stable across Tropical Western Atlantic

CV Leal, D Avelino-Alves, V Salazar, C Omachi… - Science of the Total …, 2022 - Elsevier
Sponges are among the earliest lineages of metazoans, with first fossil records dated back
to 890 million years ago. All sponge species present associations with microorganisms to …

Atom-economic macrocyclic amphiphile based on guanidinium-functionalized selenacrown ether acting as redox-responsive nanozyme

B Li, Q Xu, X Shen, T Pan, J Shang, Y Ge, Z Qi - Chinese Chemical Letters, 2023 - Elsevier
Control of self-assembly is significant to the preparation of supramolecular materials, but the
control of hydration, responsiveness, dimension, catalysis of macrocyclic amphiphiles in an …

Discovery, biosynthetic origin, and heterologous production of massinidine, an antiplasmodial alkaloid

BK Lombe, L Winand, J Diettrich, M Tobermann… - Organic …, 2022 - ACS Publications
Bacteria of the genus Massilia represent an underexplored source of bioactive natural
products. Here, we report the discovery of massinidine (1), a guanidine alkaloid with …

Structural characterization and immunomodulatory activity of an exopolysaccharide from marine-derived Aspergillus versicolor SCAU141

K Wu, Y Li, Y Lin, B Xu, J Yang, L Mo, R Huang… - International Journal of …, 2023 - Elsevier
Until now, relatively little is known about marine-derived fungal polysaccharides and their
activities. Exopolysaccharide AVP141-A was isolated from the broth of marine-derived …

Chemical Ecology of the North American Newt Genera Taricha and Notophthalmus

CT Hanifin, Y Kudo, M Yotsu-Yamashita - Progress in the Chemistry of …, 2022 - Springer
Abstract The North American newt genera Taricha and Notophthalmus (order Caudata) are
well known for the combination of potent toxicity, aposematic coloration, and striking defense …

Constructing Saturated Guanidinum Heterocycles by Cycloaddition of N-Amidinyliminium Ions with Indoles

TK Allred, MB Shaghafi, PP Chen, Q Tran… - Organic …, 2021 - ACS Publications
We report that structurally complex guanidinium heterocycles can be prepared in one step
by regio-and stereoselective [4+ 2]-cycloadditions of N-amidinyliminium ions with indoles or …