In order to study the differential protein expression in complex biological samples, strategies
for rapid, highly reproducible and accurate quantification are necessary. Isotope labeling …

Mass spectrometry (MS)–based high-throughput proteomics is the core technique for large-
scale protein characterization. Due to the extreme complexity of proteomes, sophisticated …

Modern research in food science and nutrition is moving from classical methodologies to
advanced analytical strategies in which MS‐based techniques play a crucial role. In this …

Orthogonal high-resolution separations are critical for attaining improved analytical dynamic
range and protein coverage in proteomic measurements. High-pH reversed-phase liquid …

Multi-parameter phenotypic profiling of small molecules provides important insights into their
mechanisms of action, as well as a systems level understanding of biological pathways and …

Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within
proteins are modified on multiple amino acid sidechains by diverse enzymes to create a …

With the rapid advance of MS-based proteomics one might think that 2D gel-based
proteomics is dead. This is far from the truth. Current research has shown that there are still …

Proteomics is the large-scale study of proteins, particularly their expression, structures and
functions. This still-emerging combination of technologies aims to describe and characterize …

The study of the proteome (proteomics), which includes the dynamics of protein expression,
regulation, interactions and its function, has played a less prominent role in evolutionary and …

Proteomics is a large-scale study of proteins, aiming at the description and characterization
of all expressed proteins in biological systems. The expressed proteins are typically highly …