Sepsis remains a significant cause of neonatal morbidity and mortality in China. A better
understanding of neonatal sepsis in China as compared with other industrialized and non …

Introduction The growing spread of infections caused by multidrug-resistant pathogens
makes the need of tailoring antimicrobial therapies by means of a 'patient …

Introduction Neonatal infections caused by Gram-positive bacteria are commonly treated
with vancomycin. However, there is a lack of agreement on the optimal vancomycin dosing …

Introduction: Vancomycin is commonly administered to neonates, while observational data
on therapeutic drug monitoring (TDM, trough levels) suggest that vancomycin exposure and …

Severe bacterial infections have a higher incidence in the neonatal period than at any other
pediatric age. Incidence is even higher in premature babies than in term newborns, and …

OBJECTIVE To evaluate the use of continuous infusion vancomycin in pediatric patients.
DATA SOURCES AND STUDY SELECTION PubMed, Cochrane Library, International …

Vancomycin pharmacokinetic/pharmacodynamic (PK/PD) targets have not been validated in
the neonatal population as no specifically designed studies are available. The main goal of …

Introduction: Antimicrobial treatment is quite common among hospitalized children. The
dynamic age-associated physiological variations coupled with the pathophysiological …

Purpose: Preanalytical errors comprise the majority of testing errors experienced by clinical
laboratories and significantly impact the accuracy of therapeutic drug monitoring (TDM) …

Vancomycin is a glycopeptide antibiotic that has been adopted in clinical practice to treat
gram-positive infections for more than 70 years. Despite vancomycin's long history of …