The immune system plays a crucial role in cancer development either by fostering tumor
growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It …

Acute myeloid leukemia (AML) poses a singular challenge for chimeric antigen receptor
(CAR) therapy owing to its phenotypic heterogeneity and similarity to normal hematopoietic …

Ikaros is a zinc finger transcription factor (TF) of the Krüppel family member, which
significantly regulates normal lymphopoiesis and tumorigenesis. Ikaros can directly initiate …

Epstein-Barr virus (EBV) is a human tumor virus which preferentially infects resting human B
cells. Upon infection in vitro, EBV activates and immortalizes these cells. The viral latent …

Genes encoding B lineage–restricted transcription factors are frequently mutated in B-
lymphoid leukemias, suggesting a close link between normal and malignant B-cell …

EBF1 and PAX5 mutations are associated with the development of B progenitor acute
lymphoblastic leukemia (B-ALL) in humans. To understand the molecular networks driving …

The wheat germ protein (WG) and it's proteolytic peptide have a variety of biological
activities. Our previous work showed that WG could improve immunity of the …

Despite the impressive efficacy of chimeric antigen receptor (CAR) T-cell therapy (CART) in
B-cell non-Hodgkin lymphomas, durable responses are uncommon. The histopathologic …

Background Tight regulatory loops orchestrate commitment to B cell fate within bone
marrow. Genetic lesions in this gene regulatory network underlie the emergence of the most …

The development of B cells relies on an intricate network of transcription factors critical for
developmental progression and lineage commitment. In the B cell developmental trajectory …