During active disease, patients with systemic-onset juvenile chronic arthritis (S-JCA)
demonstrate a rise and fall in serum interleukin-6 (IL-6) that parallels the classic quotidian …

▪ Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such …

A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA).
It is now clear that these cytokines play a fundamental role in the processes that cause …

During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …

Tumor necrosis factor α (TNFα) is a potent immunomodulator and proinflammatory cytokine
that has been implicated in the pathogenesis of autoimmune and infectious diseases. For …

During the last five years, the development of bioinformatics and EST databases has been
primarily responsible for the identification of many new chemokines and chemokine …

Tumor necrosis factor inhibitors (TNFi) have significantly improved treatment outcome of
rheumatic diseases since their incorporation into treatment protocols two decades ago …

Background Not all patients with rheumatoid arthritis can tolerate or respond to
methotrexate, a standard treatment for this disease. There is evidence that antitumour …

The association between chronic inflammation and increased risk of cardiovascular disease
in rheumatoid arthritis (RA) is well established. In the general population, inflammation is an …

Both antigen-specific and non-specific mechanisms may be involved in the pathogenesis of
oral lichen planus (OLP). Antigen-specific mechanisms in OLP include antigen presentation …