Despite major advances in prevention and treatment, cardiac and cerebral atherothrombotic
complications still account for substantial morbidity and mortality worldwide. In this context …

In the past few years, considerable evidence has accumulated to suggest the existence of
functionally polarized responses by the CD4+ T helper (Th)—and the CD8+ T cytotoxic (Tc) …

Anti-TNF-α treatment of rheumatoid arthritis patients markedly suppresses inflammatory
disease activity, but so far no tissue-protective effects have been reported. In contrast …

Objective To compare the incidence of anti–double‐stranded DNA (anti‐dsDNA) antibodies
in rheumatoid arthritis (RA) patients receiving either single or multiple doses of a chimeric …

Perivascular accumulation of mononuclear cells (MNCs) in the central nervous system
(CNS) and high levels of myelin autoantigen‐reactive T cells in blood and further enriched in …

OBJECTIVE: Much of what is known about the inflammatory response in the synovial
membrane (SM) of patients with osteoarthritis (OA) comes from studies of synovial tissues …

To investigate the direct role of interleukin (IL) 6 in the development of rheumatoid arthritis,
IL-6-deficient (IL-6−/−) mice were backcrossed for eight generations into C57BL/6 mice, a …

Background The NLRP3-inflammasome, implicated in the pathogenesis of several
inflammatory disorders, has been analysed in rheumatoid arthritis (RA). Methods Relative …

Rheumatoid arthritis (RA) is a chronic and debilitating autoimmune disease of unknown
etiology, characterized by chronic inflammation in the joints and subsequent destruction of …

▪ Abstract Tumor necrosis factor α (TNFα) and interleukin-1 (IL-1) are important in mediating
inflammation in rheumatoid arthritis (RA). Randomized phase II and III clinical trials of anti …