Genetic differences associated with dopamine and serotonin release mediate fear-induced bradycardia in the human brain

S Battaglia, C Nazzi, JF Thayer - Translational psychiatry, 2024 - nature.com
Fear-induced bradycardia, a transient heartbeat deceleration following exposure to threat, is
a physiological index observable in humans, especially in fear conditioning experiments …

The role of central serotonin neurons and 5-HT heteroreceptor complexes in the pathophysiology of depression: a historical perspective and future prospects

DO Borroto-Escuela, P Ambrogini… - International journal of …, 2021 - mdpi.com
Serotonin communication operates mainly in the extracellular space and cerebrospinal fluid
(CSF), using volume transmission with serotonin moving from source to target cells (neurons …

Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics

D Yadav, P Kumar - Neurochemistry international, 2022 - Elsevier
Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and …

AP Reddy, X Yin, N Sawant… - Human Molecular …, 2021 - academic.oup.com
The purpose of this study is to study the neuroprotective role of selective serotonin reuptake
inhibitor (SSRI), citalopram, against Alzheimer's disease (AD). Multiple SSRIs, including …

Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis …

AP Reddy, N Sawant, H Morton… - Human Molecular …, 2021 - academic.oup.com
In the current study, we investigated the protective role of citalopram against cognitive
decline, impaired mitochondrial dynamics, defective mitochondrial biogenesis, defective …

[HTML][HTML] HTR1D functions as a key target of HOXA10-AS/miR-340-3p axis to promote the malignant outcome of pancreatic cancer via PI3K-AKT signaling pathway

W Wu, Q Li, Z Zhu, C Li, P Lu, X Zhou… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Competing endogenous RNAs (ceRNAs) are a newly discovered class of molecular
regulators involved in many diseases, especially tumors. Therefore, exploration of the …

Impact of anxiety and depression across childhood and adolescence on adverse outcomes in young adulthood: A UK birth cohort study

I Morales-Muñoz, PK Mallikarjun… - The British Journal of …, 2023 - cambridge.org
Background Little is still known about the long-term impact of childhood and adolescent
persistent depression and anxiety in adulthood. Aims To investigate the impact of persistent …

A Reliable Method Based on Liquid Chromatography–Tandem Mass Spectrometry for the Simultaneous Quantification of Neurotransmitters in Caenorhabditis elegans

AK Weishaupt, L Kubens, L Ruecker, T Schwerdtle… - Molecules, 2023 - mdpi.com
Neurotransmitters like dopamine (DA), serotonin (SRT), γ-aminobutyric acid (GABA) and
acetylcholine (ACh) are messenger molecules that play a pivotal role in transmitting …

Modulation of immunity by tryptophan microbial metabolites

S Li - Frontiers in Nutrition, 2023 - frontiersin.org
Tryptophan (Trp) is an essential amino acid that can be metabolized via endogenous and
exogenous pathways, including the Kynurenine Pathway, the 5-Hydroxyindole Pathway …

Probiotic effector compounds: Current knowledge and future perspectives

EBM Daliri, FK Ofosu, C Xiuqin, R Chelliah… - Frontiers in …, 2021 - frontiersin.org
Understanding the mechanism behind probiotic action will enable a rational selection of
probiotics, increase the chances of success in clinical studies and make it easy to …