During brain development, the sequence of developmental steps and the underlying
transcriptional regulatory logic are largely conserved across species. However, the temporal …

The heart undergoes a dynamic maturation process following birth, in response to a wide
range of stimuli, including both physiological and pathological cues. This process entails …

Utilization of lipids as energy substrates after birth causes cardiomyocyte (CM) cell-cycle
arrest and loss of regenerative capacity in mammalian hearts. Beyond energy provision …

After myocardial infarction (MI), mammalian hearts do not regenerate, and the
microenvironment is disrupted. Hippo signaling loss of function with activation of …

Cardiovascular diseases (CVDs) are currently the leading cause of death worldwide. In
2022, the CVDs contributed to 19.8 million deaths globally, accounting for one-third of all …

In mammal adolescence, cardiomyocytes rapidly exit the cell cycle, and heart regeneration
in adults is limited after cardiac injury. Recent work by Li et al. in Nature revealed that …

Introduction: Acute myocardial infarction (AMI) is characterized by the loss of
cardiomyocytes, which impairs cardiac function and eventually leads to heart failure. The …

The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory
complexes forming super-assembled quaternary structures whose assembly mechanisms …

The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a
critical regulator of the peroxisome, participates in various biological processes associated …

The regenerative capacity of the adult mammalian heart remains a formidable challenge in
biological research. Despite extensive investigations into the loss of regenerative potential …