The role of histone modifications: from neurodevelopment to neurodiseases
J Park, K Lee, K Kim, SJ Yi - Signal transduction and targeted therapy, 2022 - nature.com
Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …
Thirty years of HDAC inhibitors: 2020 insight and hindsight
It is now 30 years since the first report of a potent zinc-dependent histone deacetylase
(HDAC) inhibitor appeared. Since then, five HDAC inhibitors have received regulatory …
(HDAC) inhibitor appeared. Since then, five HDAC inhibitors have received regulatory …
HDAC6 as privileged target in drug discovery: A perspective
Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …
physiological functions. Besides histone modification, largely due to its cytoplasmic …
[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …
aging of the global population. Unfortunately, drugs for treating AD have been largely …
[HTML][HTML] Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective
Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …
ordination (jerking movements), cognitive and memory impairments result from …
Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm
R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …
Current pharmacotherapy and multi-target approaches for Alzheimer's disease
SL Cheong, JK Tiew, YH Fong, HW Leong, YM Chan… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
Proteostasis in Parkinson's disease: Recent development and possible implication in diagnosis and therapeutics
A Kulkarni, K Preeti, KP Tryphena, S Srivastava… - Ageing Research …, 2023 - Elsevier
The protein dyshomeostasis is identified as the hallmark of many age-related
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …
Histone modifications in Alzheimer's disease
DA Santana, MAC Smith, ES Chen - Genes, 2023 - mdpi.com
Since Late-onset Alzheimer's disease (LOAD) derives from a combination of genetic variants
and environmental factors, epigenetic modifications have been predicted to play a role in the …
and environmental factors, epigenetic modifications have been predicted to play a role in the …
The gut microbiome as a regulator of the neuroimmune landscape
LW Yu, G Agirman, EY Hsiao - Annual review of immunology, 2022 - annualreviews.org
The gut microbiome influences many host physiologies, spanning gastrointestinal function,
metabolism, immune homeostasis, neuroactivity, and behavior. Many microbial effects on …
metabolism, immune homeostasis, neuroactivity, and behavior. Many microbial effects on …