Depression and anxiety are the most prevalent neuropsychiatric disorders that have
emerged as global health concerns. Anxiolytic and antidepressant drugs, such as …

Chronic inflammatory diseases are debilitating, affect patients' quality of life, and are a
significant financial burden on health care. Inflammation is regulated by pro-inflammatory …

Purpose Magnolol (MA) exhibits anti-depressant effect by inhibiting inflammation. However,
its effect on microglia polarization remains not fully understood. Herein, our study was …

Rationale Depression has the topmost prevalence of all psychiatric diseases. It is
characterized by a high recurrence rate, disability, and numerous and mostly unclear …

Major depression disorder is a severe mental illness often linked with metabolic disorders.
Adiponectin is an adipocyte-secreted circulatory hormone with antidiabetic and glucose/lipid …

Given that available antidepressant pharmacotherapies are not optimally effective, there is a
need for alternative treatment options that are rooted in a comprehensive understanding of …

Introduction Vortioxetine is a multimodal-acting antidepressant that provides improvements
on cognitive function aside from antidepressants and anxiolytic effects. Vortioxetine has …

Depression is a common aspect of the modern lifestyle, and most patients are recalcitrant to
the current antidepressants. Fingolimod (FTY720), a sphingosine analogue approved for the …

Objective To evaluate the clinical value of systemic immune-inflammation index (SII) based
on peripheral blood neutrophil, lymphocyte, and platelet count in evaluating the subtype and …

Given the role of low-grade inflammation in the pathophysiology of major depressive
disorder (MDD), anti-inflammatory strategies may improve treatment outcomes in some …