Biomarkers for the diagnosis and management of heart failure

V Castiglione, A Aimo, G Vergaro, L Saccaro… - Heart failure …, 2022 - Springer
Heart failure (HF) is a significant cause of morbidity and mortality worldwide. Circulating
biomarkers reflecting pathophysiological pathways involved in HF development and …

Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology

MF Piepoli, M Adamo, A Barison… - European journal of …, 2022 - academic.oup.com
The heart failure epidemic is growing and its prevention, in order to reduce associated
hospital readmission rates and its clinical and economic burden, is a key issue in modern …

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure …

J Wang, B Deng, Q Liu, Y Huang, W Chen, J Li… - Cell Death & …, 2020 - nature.com
Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and is a
severe health issue faced by the elderly population. Mixed lineage kinase 3 (MLK3), a …

Targeting Cyclic Guanosine Monophosphate to Treat Heart Failure: JACC Review Topic of the Week

M Emdin, A Aimo, V Castiglione, G Vergaro… - Journal of the American …, 2020 - jacc.org
The significant morbidity and mortality associated with heart failure with reduced ejection
fraction (HFrEF) or heart failure with preserved ejection fraction (HFpEF) justify the search for …

Inflammation, anxiety, and stress in attention-deficit/hyperactivity disorder

LF Saccaro, Z Schilliger, N Perroud, C Piguet - Biomedicines, 2021 - mdpi.com
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent and serious
neurodevelopmental disorder characterized by symptoms of inattention and/or hyperactivity …

[Retracted] Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies

CA Stamerra, P Di Giosia, P Giorgini… - Oxidative Medicine …, 2022 - Wiley Online Library
Mitochondria ensure the supply of cellular energy through the production of ATP via
oxidative phosphorylation. The alteration of this process, called mitochondrial dysfunction …

Molecular mechanisms of obesity-linked cardiac dysfunction: an up-date on current knowledge

J Gutiérrez-Cuevas, A Sandoval-Rodriguez… - Cells, 2021 - mdpi.com
Obesity is defined as excessive body fat accumulation, and worldwide obesity has nearly
tripled since 1975. Excess of free fatty acids (FFAs) and triglycerides in obese individuals …

Oxidative stress and inflammation: determinants of anthracycline cardiotoxicity and possible therapeutic targets

I Fabiani, A Aimo, C Grigoratos, V Castiglione… - Heart Failure …, 2021 - Springer
Chemotherapy with anthracycline-based regimens remains a cornerstone of treatment of
many solid and blood tumors but is associated with a significant risk of cardiotoxicity, which …

Mitochondrial dysfunction in cardiovascular disease: Current status of translational research/clinical and therapeutic implications

AS Manolis, AA Manolis, TA Manolis… - Medicinal Research …, 2021 - Wiley Online Library
Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …

Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway

H Li, M Zhang, Y Wang, K Gong, T Yan, D Wang… - Food & function, 2022 - pubs.rsc.org
Heart failure (HF) is a clinical syndrome characterized by typical symptoms that usually
occur at the end stage of various heart diseases and lead to death. Daidzein (DAI), an …