Quercetin: A flavonol with multifaceted therapeutic applications?

G D'Andrea - Fitoterapia, 2015 - Elsevier
Great interest is currently centered on the biologic activities of quercetin a polyphenol
belonging to the class of flavonoids, natural products well known for their beneficial effects …

Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery

YS Wang, CY Shen, JG Jiang - Pharmacological research, 2019 - Elsevier
Depression is a widespread psychological disorder that affects up to 20% of the world's
population. Traditional Chinese medicine (TCM), with its unique curative effect in depression …

Quercetin

GS Kelly - Alternative medicine review, 2011 - go.gale.com
Quercetin is categorized as a flavonol, one of the six subclasses of flavonoid compounds
(Table 1). Flavonoids are a family of plant compounds that share a similar flavone backbone …

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: evidence for over-inhibition

CE Page, L Coutellier - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

S Chen, Y Tang, Y Gao, K Nie, H Wang, H Su… - Frontiers in …, 2022 - frontiersin.org
Depression is a global health problem with growing prevalence rates and serious impacts
on the daily life of patients. However, the side effects of currently used antidepressants …

Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice

CE Page, R Shepard, K Heslin, L Coutellier - Scientific reports, 2019 - nature.com
Reduced activity of the prefrontal cortex (PFC) is seen in mood disorders including
depression and anxiety. The mechanisms of this hypofrontality remain unclear. Because of …

Effects of quercetin supplementation on inflammatory factors and quality of life in post‐myocardial infarction patients: a double blind, placebo‐controlled, randomized …

F Dehghani, SH Sezavar Seyedi Jandaghi… - Phytotherapy …, 2021 - Wiley Online Library
Myocardial infarction (MI) is one of the leading causes of death in the world. Epidemiological
studies have shown that dietary flavonoids are inversely related to cardiovascular morbidity …

Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress

V Mehta, A Parashar, M Udayabanu - Physiology & Behavior, 2017 - Elsevier
It is now evident that chronic stress is associated with anxiety, depression and cognitive
dysfunction and very few studies have focused on identifying possible methods to prevent …

Therapeutic effects of phytochemicals and medicinal herbs on depression

G Lee, H Bae - BioMed research international, 2017 - Wiley Online Library
Background. Depression is a recurrent, common, and potentially life‐threatening psychiatric
disease related to multiple assignable causes. Although conventional antidepressant …

Natural polyphenols in the management of major depression

L Pathak, Y Agrawal, A Dhir - Expert opinion on investigational …, 2013 - Taylor & Francis
Introduction: Natural polyphenols, the non-essential micronutrients, found in array of plant
products, are known to affect various physiological and biochemical functions in the body …