Molecular characterization of upper tract urothelial carcinoma in the era of next-generation sequencing: a systematic review of the current literature
MR Hassler, F Bray, JWF Catto, AP Grollman… - European urology, 2020 - Elsevier
Context While upper tract urothelial carcinoma (UTUC) share histological appearance with
bladder cancer (BC), the former has differences in etiology and clinical phenotype consistent …
bladder cancer (BC), the former has differences in etiology and clinical phenotype consistent …
The dynamic roles of the bladder tumour microenvironment
YC Lee, HM Lam, C Rosser, D Theodorescu… - Nature Reviews …, 2022 - nature.com
Bladder cancer is a prevalent but currently understudied cancer type and patient outcomes
are poor when it progresses to the muscle-invasive stage. Current research in bladder …
are poor when it progresses to the muscle-invasive stage. Current research in bladder …
[HTML][HTML] Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer
G Vandekerkhove, JM Lavoie, M Annala… - Nature …, 2021 - nature.com
Molecular stratification can improve the management of advanced cancers, but requires
relevant tumor samples. Metastatic urothelial carcinoma (mUC) is poised to benefit given a …
relevant tumor samples. Metastatic urothelial carcinoma (mUC) is poised to benefit given a …
[HTML][HTML] Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
We uncover a tumor-suppressive process in urothelium called transcriptional-translational
conflict caused by deregulation of the central chromatin remodeling component ARID1A …
conflict caused by deregulation of the central chromatin remodeling component ARID1A …
[HTML][HTML] A combinatorial genetic strategy for exploring complex genotype–phenotype associations in cancer
Available genetically defined cancer models are limited in genotypic and phenotypic
complexity and underrepresent the heterogeneity of human cancer. Here, we describe a …
complexity and underrepresent the heterogeneity of human cancer. Here, we describe a …
Infigratinib in upper tract urothelial carcinoma versus urothelial carcinoma of the bladder and its association with comprehensive genomic profiling and/or cell‐free …
Background Infigratinib (BGJ398) is a potent and selective fibroblast grown factor receptor 1
to 3 (FGFR1‐3) inhibitor with significant activity in patients with advanced or metastatic …
to 3 (FGFR1‐3) inhibitor with significant activity in patients with advanced or metastatic …
[HTML][HTML] Spatial immunephenotypes of distant metastases but not matched primary urothelial carcinomas predict response to immune checkpoint inhibition
Background The value of programmed cell death ligand-1 (PD-L1) to predict durable
responses to immune checkpoint inhibitors (ICIs) in metastatic urothelial carcinoma (mUC) is …
responses to immune checkpoint inhibitors (ICIs) in metastatic urothelial carcinoma (mUC) is …
Metastatic bladder cancer expression and subcellular localization of Nectin-4 and Trop-2 in variant histology: A rapid autopsy study
Abstract Background Nectin-4 and Trop-2 are transmembrane targets of FDA-approved
antibody-drug conjugates (ADC) Enfortumab-vedotin (EV) and Sacituzumab govitecan (SG) …
antibody-drug conjugates (ADC) Enfortumab-vedotin (EV) and Sacituzumab govitecan (SG) …
[HTML][HTML] Genomic heterogeneity as a barrier to precision oncology in urothelial cancer
Precision oncology relies on the accurate molecular characterization of individual patients
with cancer at the time of treatment initiation. However, tumor molecular profiles are not …
with cancer at the time of treatment initiation. However, tumor molecular profiles are not …
[HTML][HTML] Insights into the metastatic cascade through research autopsies
S Hessey, P Fessas, S Zaccaria, M Jamal-Hanjani… - Trends in Cancer, 2023 - cell.com
Metastasis is a complex process and the leading cause of cancer-related death globally.
Recent studies have demonstrated that genomic sequencing data from paired primary and …
Recent studies have demonstrated that genomic sequencing data from paired primary and …