[HTML][HTML] Xanthine oxidoreductase: A leading actor in cardiovascular disease drama

L Polito, M Bortolotti, MG Battelli, A Bolognesi - Redox Biology, 2021 - Elsevier
Cardiovascular diseases (CVD) are the leading cause of global mortality and their
pathogenesis lies mainly in the atherosclerotic process. There are close connections linking …

Advances in pharmacotherapies for hyperuricemia

F Piani, D Agnoletti, C Borghi - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Hyperuricemia is an overlooked cardiovascular and renal risk factor.
Epidemiological and genetic studies have shown an independent role of uric acid in the risk …

Large-scale cross-ancestry genome-wide meta-analysis of serum urate

C Cho, B Kim, DS Kim, MY Hwang, I Shim… - Nature …, 2024 - nature.com
Hyperuricemia is an essential causal risk factor for gout and is associated with
cardiometabolic diseases. Given the limited contribution of East Asian ancestry to genome …

Non-haemodynamic mechanisms underlying hypertension-associated damage in target kidney components

E Russo, E Bussalino, L Macciò, D Verzola… - International Journal of …, 2023 - mdpi.com
Arterial hypertension (AH) is a global challenge that greatly impacts cardiovascular
morbidity and mortality worldwide. AH is a major risk factor for the development and …

Diagnostic and prognostic role of CD93 in cardiovascular disease: a systematic review

F Piani, G Tossetta, G Cara-Fuentes, D Agnoletti… - Biomolecules, 2023 - mdpi.com
Introduction. Cluster of Differentiation (CD) 93 (also known as complement protein 1 q
subcomponent receptor C1qR1 or C1qRp) is a transmembrane glycoprotein that can also …

Association between uric acid, carotid Intima‐Media thickness, and cardiovascular events: prospective results from the improve study

MR Mannarino, M Pirro, B Gigante… - Journal of the …, 2021 - Am Heart Assoc
Background The association between elevated serum uric acid (SUA), cardiovascular
disease (CVD) risk, and carotid atherosclerosis has long been explored, and contrasting …

Serum uric acid to creatinine ratio and risk of preeclampsia and adverse pregnancy outcomes

F Piani, D Agnoletti, A Baracchi, S Scarduelli… - Journal of …, 2023 - journals.lww.com
Objective: Preeclampsia is one of the most severe diseases among the hypertensive
disorders of pregnancy (HDP) and the leading cause of maternal and fetal morbidity and …

Association of first trimester serum uric acid with preeclampsia: An observational cohort study with propensity score matching

C Yue, C Ying, X Li - Hypertension Research, 2023 - nature.com
To elucidate whether uric acid changes in early pregnancy are associated with the
development of preeclampsia and their association with preeclampsia-related adverse …

[HTML][HTML] Pullulan-stabilized gold nanoparticles tablet as a nanozyme sensor for point-of-care applications

M Al-Kassawneh, Z Sadiq… - Sensing and Bio-Sensing …, 2022 - Elsevier
In this article, we first report the fabrication of pullulan-stabilized gold nanoparticles tablet
(AuNPs-pTab) as a point-of-care (POC) analytical device using pullulan-AuNPs solution …

Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication

M Furuhashi, Y Higashiura, M Koyama… - Hypertension …, 2021 - nature.com
Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation
in purine metabolism, is involved in reactive oxygen species generation. Plasma XOR …