The conversion of acetylcholine binding into ion conduction across the membrane is
becoming more clearly understood in terms of the structure of the receptor and its transitions …

Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …

The nicotinic acetylcholine (ACh) receptors and the other neurotransmitter-gated ion
channels have key roles in fast synaptic transmission throughout the nervous system. These …

GABA is the main inhibitory neurotransmitter in the mammalian brain. The postsynaptic
GABAA receptor/pore complex is presumed to be a pentamer typically composed of a …

The synapse is a localized neurohumoral contact between a neuron and an effector cell and
may be considered the quantum of fast intercellular communication. Analogously, the …

A family of genes coding for proteins homologous to the alpha subunit of the muscle
nicotinic acetylcholine receptor has been identified in the rat genome. These genes are …

We have stably expressed in fibroblasts different pairs of a and non-a subunits of the mouse
muscle nicotinic acetylcholine receptor (AChR). They and 6, but not the B, subunits …

Nicotinic acetylcholine (ACh) receptors convert the binding of ACh into the opening of a
cation-conducting channel. New information about the regions of the receptor most …

All eukaryotic animal cells maintain high intracellular K and low intracellular Na
concentrations, a situation which is reversed in the extracellular medium. It is the Na, K …

Revised Manuscript Received March 23, 1994® abstract: All of the potent agonists and
competitive antagonists of the acetylcholine receptors are positively charged, onium …