T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Programmed death-ligand 1 [PD-(L) 1], cytotoxic T-lymphocyte associated protein 4 (CTLA-
4), and lymphocyte-activation gene 3 (LAG-3) inhibitors are recent breakthroughs in cancer …

Liver fibrosis is a common pathological feature of end stage liver failure, a severe life-
threatening disease worldwide. Nonalcoholic fatty liver disease (NAFLD), especially its more …

After seeing a dramatic increase in the development and use of immunotherapy and
precision medicine over the past few decades, oncological care now embraces the start of …

Endometriosis is defined as the presence of endometrial-like glands and stroma located
outside the uterine cavity. This common, estrogen dependent, inflammatory condition affects …

Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising
approach for cancer therapy with an expectation of no significant side effects. In the human …

T cells exercise a multitude of functions such as cytotoxicity, secretion of immunomodulating
cytokines or regulation of tolerance, collectively resulting in an effective control of immune …

The process of aging is accompanied by a dynamic restructuring of the immune response, a
phenomenon known as immunosenescence. This mini-review navigates through the …

Phage display was first described by George P. Smith when it was shown that virus particles
were capable of presenting foreign proteins on their surface. The technology has paved the …