Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Autophagy is a highly conserved catabolic process and participates in a variety of cellular
biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B …

Progressively increasing failure rates, high cost, poor bioavailability, poor safety, limited
efficacy, and a lengthy design and testing process associated with cancer drug development …

Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …

Drug repurposing is a strategy consisting of finding new indications for already known
marketed drugs used in various clinical settings or highly characterized compounds despite …

Haploidentical hematopoietic stem cell transplantation (HSCT) performed using bone
marrow (BM) grafts and post-transplantation cyclophosphamide (PTCy) has gained much …

An important mediator of cytokine signaling implicated in regulation of hematopoiesis is the
PI3K/protein kinase B (PKB/c-Akt) signaling module. Constitutive activation of this signaling …

Abstract The phosphatidylinositiol 3-kinase (PI3K), AKT, mammalian target of rapamycin
(mTOR) signaling pathway (PI3K/AKT/mTOR) is frequently dysregulated in disorders of cell …

Since angiogenesis is critical for tumor growth and metastasis, anti-angiogenic treatment is
a highly promising therapeutic approach. Thus, for over last couple of decades, there has …

Niclosamide, previously used as an anthelmintic drug is currently being repurposed for its
anticancer activity. Niclosamide is a brick like biopharmaceutical classification system (BCS) …