Self-assembling doxorubicin prodrug forming nanoparticles for cancer chemotherapy: synthesis and anticancer study in vitro and in vivo
P Gou, W Liu, W Mao, J Tang, Y Shen… - Journal of Materials …, 2013 - pubs.rsc.org
The clinical utility of doxorubicin (DOX) is restricted by its severe side effects. Continuous
efforts are aimed at developing efficacious DOX-delivery systems that may overcome the …
efforts are aimed at developing efficacious DOX-delivery systems that may overcome the …
Shaped stimuli-responsive hydrogel particles: syntheses, properties and biological responses
The ability to create nano-and micro-sized hydrogel matrices of well-defined shapes can
provide a powerful means not only to mimic the key properties of biological systems, but also …
provide a powerful means not only to mimic the key properties of biological systems, but also …
Improved anti‐tumor activity of stabilized anthracycline polymeric micelle formulation, NC‐6300
M Harada, I Bobe, H Saito, N Shibata… - Cancer …, 2011 - Wiley Online Library
Anthracyclines have long been considered to be among the most active agents clinically
available for the treatment of breast cancer despite their toxicity. To improve their …
available for the treatment of breast cancer despite their toxicity. To improve their …
Bioengineering strategies for designing targeted cancer therapies
AA Alexander-Bryant, WSV Berg-Foels… - Advances in cancer …, 2013 - Elsevier
The goals of bioengineering strategies for targeted cancer therapies are (1) to deliver a high
dose of an anticancer drug directly to a cancer tumor,(2) to enhance drug uptake by …
dose of an anticancer drug directly to a cancer tumor,(2) to enhance drug uptake by …
Cellular delivery of doxorubicin via pH-controlled hydrazone linkage using multifunctional nano vehicle based on poly (β-L-malic acid)
Doxorubicin (DOX) is currently used in cancer chemotherapy to treat many tumors and
shows improved delivery, reduced toxicity and higher treatment efficacy when being part of …
shows improved delivery, reduced toxicity and higher treatment efficacy when being part of …
PolyMPC–doxorubicin prodrugs
X Chen, SS Parelkar, E Henchey… - Bioconjugate …, 2012 - ACS Publications
We demonstrate the conjugation of the cancer drug doxorubicin (DOX) to poly
(methacryloyloxyethyl phosphorylcholine)(polyMPC), linked by hydrazone groups, using (1) …
(methacryloyloxyethyl phosphorylcholine)(polyMPC), linked by hydrazone groups, using (1) …
N‐(2‐hydroxypropyl)methacrylamide‐based polymer conjugates with pH‐controlled activation of doxorubicin. I. New synthesis, physicochemical characterization and …
New method of synthesis of water‐soluble polymer‐drug conjugates, exhibiting remarkable
anticancer activity in mice models, has been developed. In the conjugates, an anticancer …
anticancer activity in mice models, has been developed. In the conjugates, an anticancer …
Enhanced intracellular delivery of quantum dot and adenovirus nanoparticles triggered by acidic pH via surface charge reversal
H Mok, JW Park, TG Park - Bioconjugate chemistry, 2008 - ACS Publications
Quantum dot (QD) and adenovirus (ADV) nanoparticles were surface-modified with graft
copolymers that exhibited a charge reversal behavior under acidic condition. Poly (l …
copolymers that exhibited a charge reversal behavior under acidic condition. Poly (l …
Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: Impact of the carrier structure onto synergistic action in the treatment of solid …
In this study, we describe the synthesis, physico-chemical characterisation and results of the
in vitro and in vivo evaluation of the biological behaviour of N-(2-hydroxypropyl) …
in vitro and in vivo evaluation of the biological behaviour of N-(2-hydroxypropyl) …
Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting
New biodegradable star polymer–doxorubicin (Dox) conjugates designed for passive tumor
targeting were investigated and the present study described their synthesis, physico …
targeting were investigated and the present study described their synthesis, physico …