Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

Background: Nicotinamide adenine dinucleotide (NAD+) metabolism is involved in the entire
physiopathological process and is critical to human health. Long-term imbalance in NAD+ …

Background Aging is associated with impaired renal function and structural alterations.
Oxidative stress plays a vital role in renal senescence and damage. Sirtuin 1 (SIRT1) is …

Cardiovascular diseases (CVD) are the leading cause of deaths worldwide and their
prevalence is continuously increasing. Available treatments may present several side effects …

Abstract Mammalian sirtuins (SIRT1–7) are members of the nicotine adenine dinucleotide
(NAD+)-dependent family of enzymes critical for histone deacetylation and posttranslational …

Background After cerebral ischemia/reperfusion (I/R) injury, activated microglia can be
polarized towards different phenotypes (the proinflammatory M1 phenotype or the anti …

Reproduction is the way to immortality for an individual, and it is essential to the continuation
of the species. Sirtuins are involved in cellular homeostasis, energy metabolism, apoptosis …

Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer
worldwide. Therapeutic strategies are still challenging due to the high relapse rate after …

The sirtuins (SIRTs) are a family of enzymes from the group of NAD+-dependent
deacetylases. Through the reaction of splitting the acetyl group of various transcription …

Tumor necrosis factor-α (TNF-α) is an inflammatory cytokine involved in cell survival,
apoptosis, and homeostasis. However, the regulatory effect of TNF-α on mesenchymal stem …