Ovarian aging: mechanisms and intervention strategies

Z Zhu, W Xu, L Liu - Medical Review, 2023 - degruyter.com
Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced
maternal age correlates with the progressive loss of both the quantity and quality of oocytes …

Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions

W Ju, Y Zhao, Y Yu, S Zhao, S Xiang… - Frontiers in …, 2024 - frontiersin.org
Mitochondria plays an essential role in regulating cellular metabolic homeostasis,
proliferation/differentiation, and cell death. Mitochondrial dysfunction is implicated in many …

SIRT4 expression ameliorates the detrimental effect of heat stress via AMPK/mTOR signaling pathway in BMECs

Q Ding, Y Wang, SW Xia, F Zhao, JF Zhong… - International Journal of …, 2022 - mdpi.com
Sirtuin 4 (SIRT4), a member of the SIRT family, has been reported to be a key factor involved
in antioxidant defense in mitochondria. This study aimed to explore the potential molecular …

Nicotinamide Mononucleotide improves oocyte maturation of mice with type 1 diabetes

F Guo, L Wang, Y Chen, H Zhu, X Dai, X Zhang - Nutrition & Diabetes, 2024 - nature.com
Background The number of patients with type 1 diabetes rises rapidly around the world in
recent years. Maternal diabetes has a detrimental effect on reproductive outcomes due to …

Promising anti-ovarian aging herbal formulation He's Yangchao promotes in vitro maturation of oocytes from advanced maternal age mice

L Yang, J Shang, H Wang, J Ma, L Wang, Y Ma… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Marveled at the discovery of artemisinin, the world's
expectations for traditional Chinese medicine are rising. He's Yangchao formula (HSYC) is a …

[HTML][HTML] Sirtuin 4 (Sirt4) downregulation contributes to chondrocyte senescence and osteoarthritis via mediating mitochondrial dysfunction

S Lin, B Wu, X Hu, H Lu - International Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Chondrocyte senescence has recently been proposed as a key pathogenic mechanism in
the etiology of osteoarthritis (OA). Nevertheless, the precise molecular mechanisms …

Melatonin partially rescues defects induced by tranexamic acid exposure during oocyte maturation in mice

F Chen, M Zhang, Z Song, R Meng… - … of Physiology-Cell …, 2024 - journals.physiology.org
Tranexamic acid (TXA) is widely used among young women because of its ability to whiten
skin and treat menorrhagia. Nevertheless, its potential effects on oocyte maturation and …