Environmental experiences play a critical role in shaping the structure and function of the
brain. Its plasticity in response to different external stimuli has been the focus of research …

Abstract Background Apolipoprotein-E (APOE) ε4 and ε2 are the most prevalent risk-
increasing and risk-reducing genetic predictors of Alzheimer's disease, respectively …

Loneliness, common in old age, may be partially attributed to ageism. The present study
explored the short-and medium-term effect of ageism on loneliness experienced during the …

Background Loneliness can have a detrimental impact on health, yet little is known about
the association between disability and loneliness. Methods Secondary analysis of three …

Introduction Cognitive impairment (CI) is known to be mediated by several risk and
protective factors, many of which are potentially modifiable. Therefore, it is important to have …

Research shows that healthy lifestyle behavior (eg, regular physical, social, and cognitive
activity) benefits brain health, but not all communities have equal access to the knowledge …

Background: Loneliness has been declared an “epidemic” associated with negative
physical, mental, and cognitive health outcomes such as increased dementia risk. Less is …

Background It remains unknown how the patterns of change of social isolation and
loneliness are associated with the onset of cardiovascular disease (CVD) and mortality. We …

Objectives The association between loneliness and disability is a growing public health
priority. While the University of California Los Angeles Loneliness Scale (UCLA‐LS) has …

Aim This study aimed to investigate the association of social isolation, loneliness, and their
trajectory with the risk of developing type 2 diabetes mellitus (T2DM) across genetic risk …