Oxidative damage to DNA has important implications for human health and has been
identified as a key factor in the onset and development of numerous diseases. Thus, it is …

Background Ferroptosis, as a new form of cell death, is different from other cell deaths such
as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of …

The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Oxidative stress plays an important role in secondary brain injury (SBI) after intracerebral
hemorrhage (ICH), but the underling mechanism has not been fully elucidated. Recently, the …

Background and Purpose: Neuronal pyroptosis is a type of regulated cell death triggered by
proinflammatory signals. CCR5 (CC chemokine receptor 5)-mediated inflammation is …

Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury
(EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of …

Introduction Intracerebral hemorrhage (ICH) is a devastating type of stroke with high
mortality, and the effective therapies for ICH remain to be explored. Exosomes (Exos) have …

Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also
known as “Shuizhi” in traditional Chinese medicine), is the strongest natural specific inhibitor …

Cyclosporine A (CsA) is a widely used immunosuppressive agent that greatly reduces the
rates of kidney-, heart-, and liver-transplant rejection. However, CsA nephrotoxicity is a …

Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS)
following intracerebral hemorrhage (ICH) and plays an important role in secondary brain …