Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or
adult tissue stem cells via a process of self-organization that results in the formation of organ …

Drug-induced hepatotoxicity is a leading cause of drug withdrawal from the market. High-
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …

Organ‐and tissue‐level biological functions are intimately linked to microscale cell–cell
interactions and to the overarching tissue architecture. Together, biofabrication and …

X-linked myotubular myopathy (XLMTM) is a fatal congenital disorder caused by mutations
in the MTM1 gene. Currently, there are no approved treatments, although AAV8-mediated …

Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays
an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to …

Organoids are established through in vitro 3D culture, and they can mimic the structure and
physiological functions of organs or tissues in vivo. Organoids have attracted much attention …

Physiologically relevant and broadly applicable liver cell culture platforms are of great
importance in both drug development and disease modeling. Organ-on-a-chip systems offer …

Limited by the poor proliferation and restricted sources of adult hepatocytes, there is an
urgent need to find substitutes for proliferation and cultivation of mature hepatocytes in vitro …

Simple Summary Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging
from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH), which can progress to …

Circadian rhythms are endogenous oscillations with approximately a 24-h period that allow
organisms to anticipate the change between day and night. Disruptions that desynchronize …