[HTML][HTML] Chronic myeloid leukemia: reminiscences and dreams
With the deaths of Janet Rowley and John Goldman in December 2013, the world lost two
pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley, unraveled the …
pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley, unraveled the …
Meeting the needs of CML patients in resource-poor countries
H Malhotra, J Radich… - Hematology 2014, the …, 2019 - ashpublications.org
Subsequent to the development and global availability of BCR/ABL–targeted tyrosine kinase
inhibitors (TKIs), the prognosis of patients with chronic myeloid leukemia (CML), at least …
inhibitors (TKIs), the prognosis of patients with chronic myeloid leukemia (CML), at least …
Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response …
S Branford, L Fletcher, NCP Cross… - Blood, The Journal …, 2008 - ashpublications.org
An international basis for comparison of BCR-ABL mRNA levels is required for the common
interpretation of data derived from individual laboratories. This will aid clinical decisions for …
interpretation of data derived from individual laboratories. This will aid clinical decisions for …
[HTML][HTML] Measurable residual disease in chronic myeloid leukemia
S Branford, JF Apperley - Haematologica, 2022 - ncbi.nlm.nih.gov
Chronic myeloid leukemia is characterized by a single genetic abnormality resulting in a
fusion gene whose mRNA product is easily detected and quantified by reverse-transcriptase …
fusion gene whose mRNA product is easily detected and quantified by reverse-transcriptase …
New approaches to molecular monitoring in CML (and other diseases)
Chronic myeloid leukemia (CML) is the model cancer, demonstrating the clinical benefits of
targeted therapy and the power of molecular diagnostics and monitoring. In CML, the BCR …
targeted therapy and the power of molecular diagnostics and monitoring. In CML, the BCR …
[HTML][HTML] Molecular techniques for the personalised management of patients with chronic myeloid leukaemia
Chronic myeloid leukemia (CML) is the paradigm for targeted cancer therapy. RT-qPCR is
the gold standard for monitoring response to tyrosine kinase-inhibitor (TKI) therapy based on …
the gold standard for monitoring response to tyrosine kinase-inhibitor (TKI) therapy based on …
Is adherence to imatinib mesylate treatment among patients with chronic myeloid leukemia associated with better clinical outcomes in Qatar?
Background Despite the revolutionary success of introducing tyrosine kinase inhibitors
(TKIs), such as imatinib mesylate (IM), for treating chronic myeloid leukemia (CML), a …
(TKIs), such as imatinib mesylate (IM), for treating chronic myeloid leukemia (CML), a …
Management of myeloproliferative neoplasms in the molecular era: from research to practice
K Pettit, A Rezazadeh, EL Atallah… - American Society of …, 2022 - ascopubs.org
The 1960 discovery of the Philadelphia chromosome in chronic myeloid leukemia (CML)
marked the beginning of the modern genomic era of oncology. In the following years, the …
marked the beginning of the modern genomic era of oncology. In the following years, the …
Precision medicine in low-and middle-income countries
JP Radich, E Briercheck, DT Chiu… - Annual Review of …, 2022 - annualreviews.org
Most cancer cases occur in low-and middle-income countries (LMICs). The sophisticated
technical and human infrastructure needed for optimal diagnosis, treatment, and monitoring …
technical and human infrastructure needed for optimal diagnosis, treatment, and monitoring …
Current trends in molecular diagnostics of chronic myeloid leukemia
Nearly 1.5 million people worldwide suffer from chronic myeloid leukemia (CML),
characterized by the genetic translocation t (9; 22)(q34; q11. 2), involving the fusion of the …
characterized by the genetic translocation t (9; 22)(q34; q11. 2), involving the fusion of the …