Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The function of neuronal circuits relies on the properties of individual neuronal cells and
their synapses. We propose that a substantial degree of synapse formation and function is …

Splicing varies across brain regions, but the single-cell resolution of regional variation is
unclear. We present a single-cell investigation of differential isoform expression (DIE) …

The assembly and specification of synapses in the brain is incompletely understood,–.
Latrophilin-3 (encoded by Adgrl3, also known as Lphn3)—a postsynaptic adhesion G …

Cortical interneurons display striking differences in shape, physiology, and other attributes,
challenging us to appropriately classify them. We previously suggested that interneuron …

Neurons use local protein synthesis to support their morphological complexity, which
requires independent control across multiple subcellular compartments up to the level of …

Mechanisms governing how immune cells and their derived molecules impact homeostatic
brain function are still poorly understood. Here, we elucidate neuronal mechanisms …

Genes encoding cell-surface proteins control nervous system development and are
implicated in neurological disorders. These genes produce alternative mRNA isoforms …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

A major obstacle to treating Alzheimer's disease (AD) is our lack of understanding of the
molecular mechanisms underlying selective neuronal vulnerability, a key characteristic of …