[HTML][HTML] Targeting cancer stem cell pathways for cancer therapy

L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity

JYC Park, A King, V Björk, BW English… - … of Physiology-Cell …, 2023 - journals.physiology.org
The extracellular matrix (ECM), composed of interlinked proteins outside of cells, is an
important component of the human body that helps maintain tissue architecture and cellular …

[HTML][HTML] Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and …

J Nathansen, V Lukiyanchuk, L Hein, MI Stolte… - Oncogene, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an
advanced stage, conferring a poor prognosis. The probability of local tumor control after …

MiR-124 reversed the doxorubicin resistance of breast cancer stem cells through STAT3/HIF-1 signaling pathways

C Liu, H Xing, C Guo, Z Yang, Y Wang, Y Wang - Cell Cycle, 2019 - Taylor & Francis
Various drug treatments including doxorubicin (DOX) have been proved efficient in the
suppression of breast cancer. Nonetheless, drug resistance became an obstacle in the …

[HTML][HTML] The impact of iron chelators on the biology of cancer stem cells

J Szymonik, K Wala, T Górnicki, J Saczko… - International Journal of …, 2021 - mdpi.com
Neoplastic diseases are still a major medical challenge, requiring a constant search for new
therapeutic options. A serious problem of many cancers is resistance to anticancer drugs …

A Quenched Annexin V‐Fluorophore for the Real‐Time Fluorescence Imaging of Apoptotic Processes In Vitro and In Vivo

H Kim, HY Kim, EY Lee, BK Choi, H Jang… - Advanced …, 2020 - Wiley Online Library
Annexin‐based probes have long been used to study apoptotic cell death, which is of key
importance to many areas of biological research, drug discovery, and clinical applications …

[HTML][HTML] Hypoxia-induced cancer cell reprogramming: a review on how cancer stem cells arise

GM Abd, MC Laird, JC Ku, Y Li - Frontiers in Oncology, 2023 - ncbi.nlm.nih.gov
Cancer stem cells are a subset of cells within the tumor that possess the ability to self-renew
as well as differentiate into different cancer cell lineages. The exact mechanisms by which …

Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY

PH Vogt, B Besikoglu, M Bettendorf… - Human …, 2019 - academic.oup.com
Abstract STUDY QUESTION Which Y genes mapped to the 'Gonadoblastoma Y (GBY)'locus
on human Y chromosome are expressed in germ cells of individuals with some Differences …

[HTML][HTML] Oct4 controls basement membrane development during human embryogenesis

M Rosner, M Hengstschläger - Developmental Cell, 2024 - cell.com
Basement membranes (BMs) are sheet-like structures of extracellular matrix (ECM) that
provide structural support for many tissues and play a central role in signaling. They are key …

[PDF][PDF] Exercise potentially prevents colorectal cancer liver metastases by suppressing tumor epithelial cell stemness via RPS4X downregulation

R Wan, Y Chen, X Feng, Z Luo, Z Peng, B Qi, H Qin… - Heliyon, 2024 - cell.com
Background Colorectal cancer (CRC) is the third most prevalent tumor globally. The liver is
the most common site for CRC metastasis, and the involvement of the liver is a common …