[HTML][HTML] Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity
JYC Park, A King, V Björk, BW English… - … of Physiology-Cell …, 2023 - journals.physiology.org
The extracellular matrix (ECM), composed of interlinked proteins outside of cells, is an
important component of the human body that helps maintain tissue architecture and cellular …
important component of the human body that helps maintain tissue architecture and cellular …
[HTML][HTML] Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and …
J Nathansen, V Lukiyanchuk, L Hein, MI Stolte… - Oncogene, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an
advanced stage, conferring a poor prognosis. The probability of local tumor control after …
advanced stage, conferring a poor prognosis. The probability of local tumor control after …
MiR-124 reversed the doxorubicin resistance of breast cancer stem cells through STAT3/HIF-1 signaling pathways
C Liu, H Xing, C Guo, Z Yang, Y Wang, Y Wang - Cell Cycle, 2019 - Taylor & Francis
Various drug treatments including doxorubicin (DOX) have been proved efficient in the
suppression of breast cancer. Nonetheless, drug resistance became an obstacle in the …
suppression of breast cancer. Nonetheless, drug resistance became an obstacle in the …
[HTML][HTML] The impact of iron chelators on the biology of cancer stem cells
J Szymonik, K Wala, T Górnicki, J Saczko… - International Journal of …, 2021 - mdpi.com
Neoplastic diseases are still a major medical challenge, requiring a constant search for new
therapeutic options. A serious problem of many cancers is resistance to anticancer drugs …
therapeutic options. A serious problem of many cancers is resistance to anticancer drugs …
A Quenched Annexin V‐Fluorophore for the Real‐Time Fluorescence Imaging of Apoptotic Processes In Vitro and In Vivo
Annexin‐based probes have long been used to study apoptotic cell death, which is of key
importance to many areas of biological research, drug discovery, and clinical applications …
importance to many areas of biological research, drug discovery, and clinical applications …
[HTML][HTML] Hypoxia-induced cancer cell reprogramming: a review on how cancer stem cells arise
Cancer stem cells are a subset of cells within the tumor that possess the ability to self-renew
as well as differentiate into different cancer cell lineages. The exact mechanisms by which …
as well as differentiate into different cancer cell lineages. The exact mechanisms by which …
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY
PH Vogt, B Besikoglu, M Bettendorf… - Human …, 2019 - academic.oup.com
Abstract STUDY QUESTION Which Y genes mapped to the 'Gonadoblastoma Y (GBY)'locus
on human Y chromosome are expressed in germ cells of individuals with some Differences …
on human Y chromosome are expressed in germ cells of individuals with some Differences …
[HTML][HTML] Oct4 controls basement membrane development during human embryogenesis
M Rosner, M Hengstschläger - Developmental Cell, 2024 - cell.com
Basement membranes (BMs) are sheet-like structures of extracellular matrix (ECM) that
provide structural support for many tissues and play a central role in signaling. They are key …
provide structural support for many tissues and play a central role in signaling. They are key …
[PDF][PDF] Exercise potentially prevents colorectal cancer liver metastases by suppressing tumor epithelial cell stemness via RPS4X downregulation
Background Colorectal cancer (CRC) is the third most prevalent tumor globally. The liver is
the most common site for CRC metastasis, and the involvement of the liver is a common …
the most common site for CRC metastasis, and the involvement of the liver is a common …