Alzheimer's disease (AD) is a devastating neurodegenerative disease with limited
therapeutic options. Cellular transplantation of healthy exogenic neurons to replace and …

Excitatory projection neurons and inhibitory interneurons primarily accomplish the neural
activity of the cerebral cortex, and an imbalance of excitatory-inhibitory neural networks may …

K-Cl transporter KCC2 is an important regulator of neuronal development and neuronal
function at maturity. Through its canonical transporter role, KCC2 maintains inhibitory …

Inhibitory modulation of glutamatergic information processing is a prerequisite for proper
network function. Among the many groups of interneurons (INs), somatostatin-expressing …

Interneuron progenitor transplantation can ameliorate disease symptoms in a variety of
neurological disorders. The strategy is based on transplantation of embryonic medial …

Multi-recording techniques show evidence that neurons coordinate their firing forming
ensembles and that brain networks are made by connections between ensembles. While …

Motivation The molecular identity of a cell results from a complex interplay between
heterogeneous molecular layers. Recent advances in single-cell sequencing technologies …

Introduction Enhancer of zeste homolog 2 (Ezh2) is responsible for trimethylation of histone
3 at lysine 27 (H3K27me3), resulting in repression of gene expression. Here, we explore the …

Accepted: 28 March 2024© Center for Excellence in Brain Science and Intelligence
Technology, Chinese Academy of Sciences 2024 ganglionic eminence (CGE), with …

A decreased expression of specific interneuron subtypes, containing either the calcium
binding protein parvalbumin (PV) or the neurotransmitter somatostatin (SST), are observed …