Lung cancer immunotherapy: progress, pitfalls, and promises

A Lahiri, A Maji, PD Potdar, N Singh, P Parikh, B Bisht… - Molecular cancer, 2023 - Springer
Lung cancer is the primary cause of mortality in the United States and around the globe.
Therapeutic options for lung cancer treatment include surgery, radiation therapy …

Toward personalized treatment approaches for non-small-cell lung cancer

M Wang, RS Herbst, C Boshoff - Nature medicine, 2021 - nature.com
Worldwide, lung cancer is the most common cause of cancer-related deaths. Molecular
targeted therapies and immunotherapies for non-small-cell lung cancer (NSCLC) have …

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

Artificial intelligence in lung cancer diagnosis and prognosis: Current application and future perspective

S Huang, J Yang, N Shen, Q Xu, Q Zhao - Seminars in Cancer Biology, 2023 - Elsevier
Lung cancer is one of the malignant tumors with the highest incidence and mortality in the
world. The overall five-year survival rate of lung cancer is relatively lower than many leading …

N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non …

Z Liu, T Wang, Y She, K Wu, S Gu, L Li, C Dong… - Molecular cancer, 2021 - Springer
Background An in-depth understanding of immune evasion mechanisms in tumors is crucial
to overcome resistance and enable innovative advances in immunotherapy. Circular RNAs …

Integrative proteomic characterization of human lung adenocarcinoma

JY Xu, C Zhang, X Wang, L Zhai, Y Ma, Y Mao, K Qian… - Cell, 2020 - cell.com
Genomic studies of lung adenocarcinoma (LUAD) have advanced our understanding of the
disease's biology and accelerated targeted therapy. However, the proteomic characteristics …

The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing

C Wang, Q Yu, T Song, Z Wang, L Song… - … and Targeted Therapy, 2022 - nature.com
A thorough interrogation of the immune landscape is crucial for immunotherapy strategy
selection and prediction of clinical responses in non-small-cell lung cancer (NSCLC) …

The biology and management of non-small cell lung cancer

RS Herbst, D Morgensztern, C Boshoff - Nature, 2018 - nature.com
Important advancements in the treatment of non-small cell lung cancer (NSCLC) have been
achieved over the past two decades, increasing our understanding of the disease biology …

Perioperative toripalimab plus chemotherapy for patients with resectable non–small cell lung cancer: the neotorch randomized clinical trial

S Lu, W Zhang, L Wu, W Wang, P Zhang, W Fang… - Jama, 2024 - jamanetwork.com
Importance Adjuvant and neoadjuvant immunotherapy have improved clinical outcomes for
patients with early-stage non–small cell lung cancer (NSCLC). However, the optimal …

Deep learning for lung cancer prognostication: a retrospective multi-cohort radiomics study

A Hosny, C Parmar, TP Coroller, P Grossmann… - PLoS …, 2018 - journals.plos.org
Background Non-small-cell lung cancer (NSCLC) patients often demonstrate varying clinical
courses and outcomes, even within the same tumor stage. This study explores deep …