FGFR inhibition augments anti–PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression
The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of
intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) …
intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) …
[HTML][HTML] Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
The antiviral DNA cytosine deaminase APOBEC3B has been implicated as a source of
mutation in many cancers. However, despite years of work, a causal relationship has yet to …
mutation in many cancers. However, despite years of work, a causal relationship has yet to …
Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
Histone H2A lysine 119 (H2AK119Ub) is monoubiquitinated by Polycomb repressive
complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB) …
complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB) …
[HTML][HTML] Fibroblast growth factor receptor 3 mutation attenuates response to immune checkpoint blockade in metastatic urothelial carcinoma by driving …
Y Song, Y Peng, C Qin, Y Wang, W Yang… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Immune checkpoint blockade (ICB) therapy holds promise in metastatic
urothelial carcinoma (UC). Fibroblast growth factor receptor 3 (FGFR3) mutation drives T-cell …
urothelial carcinoma (UC). Fibroblast growth factor receptor 3 (FGFR3) mutation drives T-cell …
Spatial relationships in the tumor microenvironment demonstrate association with pathologic response to Neoadjuvant Chemoimmunotherapy in muscle-invasive …
W Beckabir, SE Wobker, JS Damrauer, B Midkiff… - European urology, 2024 - Elsevier
Background Platinum-based neoadjuvant chemotherapy (NAC) is standard for patients with
muscle-invasive bladder cancer (MIBC). Pathologic response (complete: ypT0N0 and …
muscle-invasive bladder cancer (MIBC). Pathologic response (complete: ypT0N0 and …
A large-scale meta-analysis reveals positive feedback between macrophages and T cells that sensitizes tumors to immunotherapy
Although considerable efforts have been dedicated to identifying predictive signatures for
immune checkpoint inhibitor (ICI) treatment response, current biomarkers suffer from poor …
immune checkpoint inhibitor (ICI) treatment response, current biomarkers suffer from poor …
Immune features are associated with response to neoadjuvant chemo-immunotherapy for muscle-invasive bladder cancer
Neoadjuvant cisplatin-based chemotherapy is standard of care for muscle-invasive bladder
cancer (MIBC). Immune checkpoint inhibition (ICI) alone, and ICI in combination with …
cancer (MIBC). Immune checkpoint inhibition (ICI) alone, and ICI in combination with …
Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant
Background p53, the most frequently mutated gene in cancer, lacks effective targeted drugs.
Methods We developed monoclonal antibodies (mAbs) that target a p53 hotspot mutation …
Methods We developed monoclonal antibodies (mAbs) that target a p53 hotspot mutation …
[HTML][HTML] Phase II study of a trastuzumab biosimilar in combination with paclitaxel for HER2-positive recurrent or metastatic urothelial carcinoma: KCSG GU18-18
Background Human epidermal growth factor receptor 2 (HER2) is a widely explored
therapeutic target in solid tumors. We evaluated the efficacy and safety of trastuzumab-pkrb …
therapeutic target in solid tumors. We evaluated the efficacy and safety of trastuzumab-pkrb …
Optimizing identification of consensus molecular subtypes in muscle-invasive bladder cancer: a comparison of two sequencing methods and gene sets using FFPE …
FJ Koll, C Döring, C Olah, T Szarvas, J Köllermann… - BMC cancer, 2023 - Springer
Background Molecular subtypes predict prognosis in muscle-invasive bladder cancer
(MIBC) and are explored as predictive markers. To provide a common base for molecular …
(MIBC) and are explored as predictive markers. To provide a common base for molecular …