B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

T cells are integral components of the adaptive immune system, and their responses are
mediated by unique T-cell receptors (TCR) that recognize specific antigens from a variety of …

Immune thrombocytopenia (ITP) is traditionally considered an antibody-mediated disease.
However, a number of features suggest alternative mechanisms of platelet destruction. In …

Autologous haematopoietic stem cell transplantation (AHSCT) is a vital therapeutic option
for patients with highly active multiple sclerosis (MS). Rates of remission suggest AHSCT is …

T-cell receptor (TCR) repertoire diversity is a determining factor for the immune system
capability in fighting infections and preventing autoimmunity. During life, the TCR repertoire …

B and T cell receptor (immune) repertoires can represent an individual's immune history.
While current repertoire analysis methods aim to discriminate between health and disease …

Thymic T cell development comprises T cell receptor (TCR) recombination and assessment
of TCR avidity towards self-peptide-MHC complexes presented by antigen-presenting cells …

Abstract Changes in the T cell receptor (TCR) repertoires have become important markers
for monitoring disease or therapy progression. With the rise of immunotherapy usage in …

Evidence of the effectiveness of B-cell-depleting monoclonal antibodies (mAbs) in multiple
sclerosis (MS) prompted a partial revisitation of the pathogenetic paradigm of the disease …

T-cell receptor (TCR) analysis is relevant for the study of immune system diseases. The
expression of TCRs is usually measured with targeted sequencing approaches where TCR …