We have evaluated the mechanism by which interleukin-1β (IL-1β) increases amnion cell
PGE 2 production in a concentration-dependent manner. IL-1β-stimulated amnion cell PGE …

Maturation of the fetal hypothalamic-pituitary-axis may be an important factor in the
stimulation of the onset of parturition. Recent studies have found that corticotrophin …

Amnion‐derived prostaglandin E2 (PGE2) and cortisol are key to labor onset. Identification
of a common transcription factor driving the expression of both cyclooxygenase‐2 (COX‐2) …

REPRODUCTION Page 1 REPRODUCTION RESEARCH Prostaglandin F2a regulates the
expression of uterine activation proteins via multiple signalling pathways Chen Xu*, Xingji …

OBJECTIVE: To investigate the changes of nuclear factor kappa B (NF-κB), cyclooxygenase-
2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in human term myometrium before and …

Human parturition is associated with massive arachidonic acid (AA) mobilization in the
amnion, indicating that large amounts of AA-derived eicosanoids are required for parturition …

Several pharmacologic agents capable of inducing abortion have become available in the
last 20 years. Prostaglandins cause powerful contractions of the uterus that lead eventually …

The inflammatory process is known to cause preterm delivery. Recently, a cyclooxygenase
(COX)-2 inhibitor has been developed as an anti-inflammatory drug with few side-effects …

Prostaglandin (PG) production by intrauterine tissues plays a key part in the control of
pregnancy and parturition. The present study was to investigate the role of placenta-derived …

A diet rich in n-3 polyunsaturated fatty acid (PUFA) may reduce the intrauterine production of
prostaglandins and prolong pregnancy. We tested this hypothesis by assessing the …