Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

Autoimmune liver diseases are chronic inflammatory hepatobiliary disorders that when
classically defined encompass three distinctive clinical presentations; primary biliary …

Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver
and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …

Primary biliary cholangitis is an autoimmune liver disease that predominantly affects women.
It is characterised by a chronic and destructive, small bile duct, granulomatous lymphocytic …

Hong You1· Xiong Ma2· Cumali Efe3· Guiqiang Wang4· Sook‑Hyang Jeong5· Kazumichi
Abe6· Weijia Duan1· Sha Chen1· Yuanyuan Kong7· Dong Zhang8· Lai Wei9· Fu‑Sheng …

CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …

Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune liver disease
characterized by a destructive, small duct, and lymphocytic cholangitis, and marked by the …

Infectious diseases are commonly implicated as potential initiators of autoimmune diseases
(ADs) and represent the most commonly known factor in the development of autoimmunity in …

Backgrounds & Aims Primary biliary cholangitis (PBC) is a chronic liver disease in which
autoimmune destruction of the small intrahepatic bile ducts eventually leads to cirrhosis …