Abstract Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes~ 50%
of kidney allograft losses each year. Despite attempts to develop well-tolerated and effective …

Myasthenia gravis (MG) is an autoimmune disorder that affects the neuromuscular junction,
leading to muscle weakness and fatigue. MG is caused by antibodies against the …

Abnormal activation of multiple immune and non-immune cells and proinflammatory factors
mediate the development of joint inflammation in genetically susceptible individuals …

Careful regulation of the complement system is critical for enabling complement proteins to
titrate immune defense while also preventing collateral tissue damage from poorly controlled …

Bloodstream infection is a major public health concern associated with high mortality and
high healthcare costs worldwide. Bacteremia can trigger fatal sepsis whose prevention …

Cardiovascular diseases are the leading cause of death globally, and atherosclerosis is the
major contributor to the development and progression of cardiovascular diseases. Immune …

Introduction The complement system is involved in numerous diseases, through diverse
mechanisms and degree of activation. With the emergence of complement targeting …

The liver is a multifunctional organ that plays crucial roles in numerous physiological
processes, such as production of bile and proteins for blood plasma, regulation of blood …

Targeting specific molecular drivers of tumor growth is a key approach in cancer therapy.
Among these targets, the low-density lipoprotein receptor-related protein 6 (LRP6), a vital …

Background Intracerebral hemorrhage (ICH) is a common cerebrovascular disease, and the
complement cascade exacerbates brain injury after ICH. As the most abundant component …