From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders
Inflammation is an essential immune response that helps fight infections and heal tissues.
However, chronic inflammation has been linked to several diseases, including cancer …
However, chronic inflammation has been linked to several diseases, including cancer …
Hematopoietic stem cell injury induced by ionizing radiation
Significance: Exposure to ionizing radiation (IR) as the result of nuclear accidents or terrorist
attacks is a significant threat and a major medical concern. Hematopoietic stem cell (HSC) …
attacks is a significant threat and a major medical concern. Hematopoietic stem cell (HSC) …
Reactive oxygen species in normal and tumor stem cells
Reactive oxygen species (ROS) play an important role in determining the fate of normal
stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self …
stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self …
Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome
V Madan, D Kanojia, J Li, R Okamoto… - Nature …, 2015 - nature.com
Somatic mutations in the spliceosome gene ZRSR2—located on the X chromosome—are
associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of …
associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of …
Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy
L Van De Laar, PJ Coffer… - Blood, The Journal of the …, 2012 - ashpublications.org
Dendritic cells (DCs) represent a small and heterogeneous fraction of the hematopoietic
system, specialized in antigen capture, processing, and presentation. The different DC …
system, specialized in antigen capture, processing, and presentation. The different DC …
Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling
PS Hole, J Zabkiewicz, C Munje… - Blood, The Journal …, 2013 - ashpublications.org
Excessive production of reactive oxygen species (ROS) is frequently observed in cancer and
is known to strongly influence hematopoietic cell function. Here we report that extracellular …
is known to strongly influence hematopoietic cell function. Here we report that extracellular …
Disease-causing mutations in SF3B1 alter splicing by disrupting interaction with SUGP1
SF3B1, which encodes an essential spliceosomal protein, is frequently mutated in
myelodysplastic syndromes (MDS) and many cancers. However, the defect of mutant SF3B1 …
myelodysplastic syndromes (MDS) and many cancers. However, the defect of mutant SF3B1 …
Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side
R Prieto-Bermejo, M Romo-González… - Journal of Experimental …, 2018 - Springer
Oxidative stress is related to ageing and degenerative diseases, including cancer. However,
a moderate amount of reactive oxygen species (ROS) is required for the regulation of …
a moderate amount of reactive oxygen species (ROS) is required for the regulation of …
S100A9 induces differentiation of acute myeloid leukemia cells through TLR4
M Laouedj, MR Tardif, L Gil, MA Raquil… - Blood, The Journal …, 2017 - ashpublications.org
Abstract S100A8 and S100A9 are calcium-binding proteins predominantly expressed by
neutrophils and monocytes and play key roles in both normal and pathological inflammation …
neutrophils and monocytes and play key roles in both normal and pathological inflammation …
Poly (ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma
Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM). Jun N-
terminal kinase (JNK) signaling has been implicated in MM pathogenesis, but its function is …
terminal kinase (JNK) signaling has been implicated in MM pathogenesis, but its function is …