In the mid 1960s, experimental work on molecules under screening as coronary dilators
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …

The development of a wide range of novel antineoplastic therapies has improved the
prognosis for patients with a wide range of malignancies, which has increased the number …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted as the document was compiled through …

Iron metabolism is a balancing act, and biological systems have evolved exquisite
regulatory mechanisms to maintain iron homeostasis. Iron metabolism disorders are …

(CAD). Hypertension is a major independent risk factor for the development of CAD, stroke,
and renal failure. The optimal choice of antihypertensive agents remains controversial, and …

Under conditions of iron overload, which are now reaching epidemic proportions worldwide,
iron-overload cardiomyopathy is the most important prognostic factor in patient survival. We …

Key Points and Practical Recommendations• Calcium channel blockers, which dilate
arteries by reducing calcium flux into cells, effectively lower blood pressure, especially in …

BACKGROUND: The prevalence of primary (hereditary) hemochromatosis and secondary
iron overload (hemosiderosis) is reaching epidemic levels worldwide. Iron-overload leads to …

Carl Erik Mogensen Medical Department M, Diabetes and Endocrinology, Aarhus
Kommunehospital, Aarhus University Hospital, Aarhus, Denmark (Modified from …

Cardiovascular disease (CVD), which encompasses a number of conditions that can affect
the heart and blood vessels, presents a major challenge for modern-day healthcare. Nearly …