Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection
Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …
disease. These drugs have not consistently demonstrated high efficacy in preventing or …
Melatonin and pathological cell interactions: Mitochondrial glucose processing in cancer cells
Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …
Melatonin ameliorates arsenic‐induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats
F Yarmohammadi, S Barangi… - …, 2023 - Wiley Online Library
Chronic arsenic (As) exposure, mainly as a result of drinking contaminated water, is
associated with cardiovascular diseases. Mitochondrial dysfunction, oxidative stress …
associated with cardiovascular diseases. Mitochondrial dysfunction, oxidative stress …
Melatonin as an antioxidant and immunomodulator in atopic dermatitis—A new look on an old story: A Review
AK Jaworek, JC Szepietowski, P Hałubiec… - Antioxidants, 2021 - mdpi.com
Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and
recurrent course, which significantly reduces the quality of life. Sleep disturbances are …
recurrent course, which significantly reduces the quality of life. Sleep disturbances are …
Metal ion homeostasis with emphasis on zinc and copper: Potential crucial link to explain the non-classical antioxidative properties of vitamin D and melatonin
Metal ion homeostasis is an essential physiological mechanism necessary for achieving an
adequate balance of these ions' concentrations in the different cellular compartments. This …
adequate balance of these ions' concentrations in the different cellular compartments. This …
Effects of Apamin on MPP+-Induced Calcium Overload and Neurotoxicity by Targeting CaMKII/ERK/p65/STAT3 Signaling Pathways in Dopaminergic Neuronal Cells
J Park, KM Jang, KK Park - International Journal of Molecular Sciences, 2022 - mdpi.com
Parkinson's disease (PD), a neurodegenerative disorder, is characterized by the loss of
dopaminergic (DA) neurons. The pathogenesis of PD is associated with several factors …
dopaminergic (DA) neurons. The pathogenesis of PD is associated with several factors …
Melatonin, its metabolites and their interference with reactive nitrogen compounds
R Hardeland - Molecules, 2021 - mdpi.com
Melatonin and several of its metabolites are interfering with reactive nitrogen. With the notion
of prevailing melatonin formation in tissues that exceeds by far the quantities in blood …
of prevailing melatonin formation in tissues that exceeds by far the quantities in blood …
Oxidant/antioxidant status is impaired in sepsis and is related to anti-apoptotic, inflammatory, and innate immunity alterations
Oxidative stress is considered pivotal in the pathophysiology of sepsis. Oxidants modulate
heat shock proteins (Hsp), interleukins (IL), and cell death pathways, including apoptosis …
heat shock proteins (Hsp), interleukins (IL), and cell death pathways, including apoptosis …
Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction
Y Miao, L Xie, J Song, X Cai, J Yang, X Ma… - Physiological …, 2024 - Wiley Online Library
Sarcopenia is a systemic skeletal muscle disease characterized by a decline in skeletal
muscle mass and function. Originally defined as an age‐associated condition, sarcopenia …
muscle mass and function. Originally defined as an age‐associated condition, sarcopenia …
Transcriptome and machine learning analysis of the impact of COVID-19 on mitochondria and multiorgan damage
YY Chang, AC Wei - Plos one, 2024 - journals.plos.org
The effects of coronavirus disease 2019 (COVID-19) primarily concern the respiratory tract
and lungs; however, studies have shown that all organs are susceptible to infection by …
and lungs; however, studies have shown that all organs are susceptible to infection by …