Background The factors governing latency in tuberculosis are not well understood but
appear to involve both the pathogen and the host. We have used tuberculin skin test (TST) …

Protective immunity and host resistance to coccidioidomycosis require a robust cell-
mediated immunity with adequate production of Th1 cytokines including interleukin-12, and …

Objective Although disseminated nontuberculous mycobacterial infection is attributed to
defects in the interleukin (IL)-12/interferon-γ circuit, the immunophenotype of idiopathic …

Type 1 cytokine responses are known to play an important role in immunity to tuberculosis
(TB) in children, although little is known about other factors that might be important. In …

The WHO estimates around a million children contract tuberculosis (TB) annually with over
80 000 deaths from dissemination of infection outside of the lungs. The insidious onset and …

Autoimmune diseases arise from atypical immune responses that attack self-tissue epitopes,
and their development is intricately connected to the disruption of the JAK-STAT signaling …

We have hypothesized that individuals infected with Mycobacterium tuberculosis that exhibit
different patterns of immune reactivity in serial interferon (IFN)-γ release assays (IGRA's) …

The field of primary immunodeficiencies (PIDs) is one of several in the area of clinical
immunology that has not been static, but rather has shown exponential growth due to …

Epitope-based DNA vaccines designed to induce T cell responses specific for
Mycobacterium tuberculosis (M. tb) are being developed as a means of addressing vaccine …

Over recent years there has been a tremendous increase in the understanding of pulmonary
immunity, mostly driven by large research efforts in understanding the basis of asthma and …