Early detection of cancer

D Crosby, S Bhatia, KM Brindle, LM Coussens, C Dive… - Science, 2022 - science.org
Survival improves when cancer is detected early. However,~ 50% of cancers are at an
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …

The future of early cancer detection

RC Fitzgerald, AC Antoniou, L Fruk, N Rosenfeld - Nature medicine, 2022 - nature.com
A proactive approach to detecting cancer at an early stage can make treatments more
effective, with fewer side effects and improved long-term survival. However, as detection …

[HTML][HTML] Molecular biomarkers for the early detection of ovarian cancer

R Zhang, MKY Siu, HYS Ngan, KKL Chan - International Journal of …, 2022 - mdpi.com
Ovarian cancer is the deadliest gynecological cancer, leading to over 152,000 deaths each
year. A late diagnosis is the primary factor causing a poor prognosis of ovarian cancer and …

Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning

M Kim, C Chen, P Wang, JJ Mulvey, Y Yang… - Nature Biomedical …, 2022 - nature.com
Serum biomarkers are often insufficiently sensitive or specific to facilitate cancer screening
or diagnostic testing. In ovarian cancer, the few established serum biomarkers are highly …

[HTML][HTML] Applications of proteomics in ovarian cancer: dawn of a new era

A Ghose, SVN Gullapalli, N Chohan, A Bolina… - Proteomes, 2022 - mdpi.com
The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The
patients present an advanced stage at diagnosis. This heterogeneous disease has …

[HTML][HTML] Cell-free DNA–based multi-cancer early detection test in an asymptomatic screening population (NHS-Galleri): design of a pragmatic, prospective randomised …

RD Neal, P Johnson, CA Clarke, SA Hamilton, N Zhang… - Cancers, 2022 - mdpi.com
Simple Summary NHS-Galleri is a randomised controlled trial that will assess how well a
blood test can reduce the number of late-stage cancers by helping to find cancers early. The …

[HTML][HTML] Multi-omics approaches for biomarker discovery in early ovarian cancer diagnosis

Y Xiao, M Bi, H Guo, M Li - EBioMedicine, 2022 - thelancet.com
Ovarian cancer (OC) is a heterogeneous disease with the highest mortality rate and the
poorest prognosis among gynecological malignancies. Because of the absence of specific …

Identifying high-grade serous ovarian carcinoma–specific extracellular vesicles by polyketone-coated nanowires

A Yokoi, M Ukai, T Yasui, Y Inokuma… - Science …, 2023 - science.org
Cancer cell–derived extracellular vesicles (EVs) have unique protein profiles, making them
promising targets as disease biomarkers. High-grade serous ovarian carcinoma (HGSOC) is …

[HTML][HTML] Deep learning-enabled pelvic ultrasound images for accurate diagnosis of ovarian cancer in China: a retrospective, multicentre, diagnostic study

Y Gao, S Zeng, X Xu, H Li, S Yao, K Song… - The Lancet Digital …, 2022 - thelancet.com
Background Ultrasound is a critical non-invasive test for preoperative diagnosis of ovarian
cancer. Deep learning is making advances in image-recognition tasks; therefore, we aimed …

Outcomes from opportunistic salpingectomy for ovarian cancer prevention

GE Hanley, CL Pearce, A Talhouk, JS Kwon… - JAMA network …, 2022 - jamanetwork.com
Importance Opportunistic salpingectomy (OS), which is the removal of fallopian tubes during
hysterectomy or instead of tubal ligation without removal of ovaries, is recommended to …